Results 21 to 30 of about 5,422 (250)

Evolution of Fucosyltransferase Genes in Vertebrates [PDF]

Journal of Biological Chemistry, 1997
Cloning and expression of chimpanzee FUT3, FUT5, and FUT6 genes confirmed the hypothesis that the gene duplications at the origin of the present human cluster of genes occurred between: (i) the great mammalian radiation 80 million years ago and (ii) the separation of man and chimpanzee 10 million years ago. The phylogeny of fucosyltransferase genes was
Dana Iordachescu, Pol-André Apoil, Stephen Henry, Rafael Oriol, Antoine Blancher, Anne Cailleau, Göran Larson, Marieta Costache, Marieta Costache, Anders Elmgren, Rosella Mollicone   +10 more
openaire   +3 more sources

Publisher Correction: Functional characterization of Schistosoma mansoni fucosyltransferases in Nicotiana benthamiana plants

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Kim van Noort, Dieu‑Linh Nguyen, Verena Kriechbaumer, Chris Hawes, Cornelis H. Hokke, Arjen Schots, Ruud H. P. Wilbers   +6 more
doaj   +1 more source

Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down

Molecules, 2021
Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive ...
Ravneet Kaur Grewal, Abdul Rajjak Shaikh, Suresh Gorle, Manjeet Kaur, Paula Alexendra Videira, Luigi Cavallo, Mohit Chawla   +6 more
doaj   +1 more source

Fucosyltransferases: structure/function studies [PDF]

Glycobiology, 2001
Alpha3-fucosyltransferases (alpha3-FucTs) catalyze the final step in the synthesis of a range of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six members of this family of enzymes have been cloned from the human genome, and their expression pattern has been shown to be highly regulated. Each enzyme has a unique
Ronald Knegtel, Bruce A. Macher, Eric H. Holmes, Theodora de Vries   +3 more
openaire   +2 more sources

Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. [PDF]

PLoS ONE, 2008
Helicobacter pylori persistently colonizes the gastric mucosa of half the human population. It is one of the most genetically diverse bacterial organisms and subvariants are continuously emerging within an H. pylori population.
Christina Nilsson, Anna Skoglund, Anthony P Moran, Heidi Annuk, Lars Engstrand, Staffan Normark   +5 more
doaj   +1 more source

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Frontiers in Oncology, 2018
Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb, and sialyl Lewisa) and type II (H2, Lewisx, Lewisy, and sialyl Lewisx) Lewis ...
Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet   +4 more
doaj   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation [PDF]

, 2018
FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases.
Bearden, David R., Burrage, Lindsay C., Craigen, William J., Emrick, Lisa, Freeze, Hudson H., Graham, Brett H., Jain, Mahim, Lee, Brendan, Ng, Bobby G., Rosenfeld, Jill A.   +9 more
core   +1 more source

Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. [PDF]

PLoS ONE, 2012
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required.
Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato   +13 more
doaj   +1 more source

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. [PDF]

, 2019
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Chang, Nai-Chuan, Chen, I-Ju, Ho, Ching-Liang, Lai, Tai-Yu, Lee, Andy Chi-Lung, Liao, Guo-Shiou, Lin, Ruey-Jen, Wu, Jen-Chine, Yeo, Hui-Ling, Yu, Alice L   +9 more
core   +2 more sources