The possible association of clusterin fucosylation changes with male fertility disorders
Scientific Reports, 2021 In the seminal plasma (n = 118) and serum (n = 90) clusterin (CLU) the fucosylation and the expression of selected fucosyltransferases (FUTs) were analyzed.
Ewa Janiszewska +4 more
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At the nexus of three kingdoms: the genome of the mycorrhizal fungus Gigaspora margarita provides insights into plant, endobacterial and fungal interactions. [PDF]
, 2020 As members of the plant microbiota, arbuscular mycorrhizal fungi (AMF, Glomeromycotina) symbiotically colonize plant roots. AMF also possess their own microbiota, hosting some uncultivable endobacteria.
Amselem, Joëlle +12 more
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Genetic signatures for Helicobacter pylori strains of West African origin. [PDF]
PLoS ONE, 2017 Helicobacter pylori is a genetically diverse bacterial species that colonizes the stomach in about half of the human population. Most persons colonized by H.
Kennady K Bullock +6 more
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GDP-L-fucose : synthesis and role in inflammation [PDF]
, 2007 GDP-L-fucose: synthesis and role in inflammation The migration of leukocytes from intravascular locations to extravascular sites is essential to the immune responses.
Niittymäki, Jaana
core
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation [PDF]
, 2017 Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has not been sought. Modern omics technologies allow characterization of functional phenomena using a
Aulchenko, Yurii S. +14 more
core +4 more sources
Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. [PDF]
, 2016 Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers.
Cho, Huan-Chieh +5 more
core
Expression signatures of cisplatin- and trametinib-treated early-stage medaka melanomas [PDF]
, 2019 Small aquarium fish models provide useful systems not only for a better understanding of the molecular basis of many human diseases, but also for first-line screening to identify new drug candidates.
Boswell, William +7 more
core +2 more sources
Sialic acids in biological and therapeutic processes: opportunities and challenges [PDF]
, 2015 It is now well documented that carbohydrates play multiple roles in biological processes, and hence are interesting targets for chemical biology and medicinal chemistry programmes.
Helen MI Osborn +3 more
core +1 more source
Human α1,3/4-Fucosyltransferases [PDF]
Journal of Biological Chemistry, 1998 An analysis of the acceptor substrate specificity of domain swap mutants of human alpha1,3/4-fucosyltransferases (FucTs) III and V has been carried out. The results demonstrate that changing Asp336 of FucT III to Ala (as in FucT V) produced a protein (III/V1) with a reduced activity with a variety of acceptors.
Anne L. Sherwood +5 more
openaire +4 more sources
Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases
Frontiers in ImmunologyMetabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and sarcoidosis and thanks to their adaptable metabolism are an attractive ...
Katarzyna Drzewicka, Zbigniew Zasłona
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