Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. [PDF]
PLoS Neglected Tropical Diseases, 2009 Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for those parasite species currently being controlled by singular, often limited strategies.
Jennifer M Fitzpatrick +7 more
doaj +1 more source
Trafficking and localization studies of recombinant α1,3-fucosyltransferase VI stably expressed in CHO cells [PDF]
, 2017 Peripheral α1,3-fucosylation of glycans occurs by the action of either one of five different α1,3-fucosyltransferases (Fuc-Ts) cloned to date. Fuc-TVI is one of the α1,3-fucosyltransferases which is capable to synthesize selectin ligands.
Berger, Eric G. +3 more
core
Arthritis Research & Therapy, 2022 Background Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane.
Hanjie Yu +11 more
doaj +1 more source
Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]
, 2009 Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E. +5 more
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The impact of elevation of total bilirubin level and etiology of the liver disease on serum N-glycosylation patterns in mice and men [PDF]
, 2010 The GlycoFibroTest and GlycoCirrhoTest are noninvasive alternatives for liver biopsy that can be used as a follow-up tool for fibrosis patients and to diagnose cirrhotic patients, respectively.
BLOMME, BRAM +5 more
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The sweet branch of metabolic engineering: cherry-picking the low-hanging sugary fruits [PDF]
, 2015 In the first science review on the then nascent Metabolic Engineering field in 1991, Dr. James E. Bailey described how improving erythropoietin (EPO) glycosylation can be achieved via metabolic engineering of Chinese hamster ovary (CHO) cells.
Rachel Chen
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Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate [PDF]
, 2018 The aim of the present study was to examine the roles of l-fucose and the glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate (CS/DS) with selected functional molecules in neural tissues.
Hayes, Anthony J., Melrose, James
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Scientific Reports, 2017 Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to ...
Ming Yu +4 more
doaj +1 more source
Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa [PDF]
, 2017 Purpose. The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins.
Gabrielli, Maria Gabriella +1 more
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Predictive glycoengineering of biosimilars using a Markov chain glycosylation model [PDF]
, 2016 Biosimilar drugs must closely resemble the pharmacological attributes of innovator products to ensure safety and efficacy to obtain regulatory approval. Glycosylation is one critical quality attribute that must be matched, but it is inherently difficult ...
Hansen, Anders Holmgaard +4 more
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