Results 71 to 80 of about 5,422 (250)

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

EBioMedicine, 2020
Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms ...
Hsuan-Hsuan Lu, Shu-Yung Lin, Rueyhung Roc Weng, Yi-Hsiu Juan, Yen-Wei Chen, Hsin-Han Hou, Zheng-Ci Hung, Giovanni Audrey Oswita, Yi-Jhen Huang, Shih-Yun Guu, Kay-Hooi Khoo, Jin-Yuan Shih, Chong-Jen Yu, Hsing-Chen Tsai   +13 more
doaj   +1 more source

Characterization of Fut10 and Fut11, Putative Alpha-1-3/4 Fucosyltransferase Genes Important for Vertebrate Development [PDF]

, 2007
Two new, putative alpha-1-3/4 fucosyltransferases ([alpha]1-3/4 Fuc-Ts), Fuc-TX and Fuc-TXI, were identified in the vertebrate genome and transcriptome sequence databases through sequence homology-based queries. These proteins have a significant sequence
Santosh K. Patnaik
core   +1 more source

The engagement of selectins and their ligands in colorectal cancer liver metastases [PDF]

, 2010
The colonization of the liver by colorectal cancer (CRC) cells is a complicated process which includes many stages, until macrometastases occur. The entrapment of malignant cells within the hepatic sinusoids and their interactions with resident non ...
Alves, Antoine, Aoki, Asai, Aychek, Ben-David, Bilzer, Bird, Blixt, Borsig, Borsig, Borsig, Braet, Bresalier, Brooks, Burdick, Burdick, Cho, Coppola, Dabrowska, Dernedde, Di Bella, Doebis, Dymicka-Piekarska, Fritzsche, Gangopadhyay, Garcia, Gout, Haier, Haier, Hakomori, Hanley, Hanley, Haraldsen, Hauser, He, Hu, Huang, Irimura, Ito, Jadhav, Klopocki, Kneuer, Knittel, Koike, Kudo, Kuhn, Laferriere, Laferriere, Lin, Liu, Malagolini, Man, Mannori, Matsumoto, Mayr, McCarty, McCarty, McLoughlin, McMillan, Mejias-Luque, Meyer, Minami, Mollicone, Muinelo-Romay, Nakamori, Nanashima, Napier, Ngan, Niers, Nihei, Opolski, Peeters, Peng, Petretti, Petzelbauer, Ragupathi, Romano, Rudmik, Sackstein, Sato, Sawada, Schluter, Sepp, Shirota, Sierko, Silverman, Sneath, Sousou, Sousou, Springer, Stevenson, Streit, Sturm, Subramaniam, Subramaniam, Subramaniam, Takada, Taura, Thomas, Thomas, Tremblay, Tremblay, Ugorski, Uner, Vekemans, Voura, Wagnerova, Wang, Wei, Wiese, Wilkins, Witz, Witz, Yamada, Yamaguchi, Yamane, Ye, Zarbock, Zhang, Zhang, Zipin   +121 more
core   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source

Transforming growth factor β signaling upregulates the expression of human GDP-fucose transporter by activating transcription factor Sp1. [PDF]

PLoS ONE, 2013
GDP-fucose transporter plays a crucial role in fucosylation of glycoproteins by providing activated fucose donor, GDP-fucose, for fucosyltransferases in the lumen of the Golgi apparatus. Fucose-containing glycans are involved in many biological processes,
Yu-Xin Xu, Anna Ma, Li Liu
doaj   +1 more source

Profiling of aminoxyTMT-labeled bovine milk oligosaccharides reveals substantial variation in oligosaccharide abundance between dairy cattle breeds. [PDF]

, 2019
Free milk oligosaccharides are bioactive molecules that function as prebiotics and prevent infections that commonly afflict developing infants. To date, few publications have examined the factors affecting bovine milk oligosaccharide production among ...
Barile, Daniela, Colet, Emeline, Duchene, Chloe, Larsen, Lotte Bach, Poulsen, Nina A, Robinson, Randall C   +5 more
core   +2 more sources

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. [PDF]

PLoS Neglected Tropical Diseases, 2009
Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for those parasite species currently being controlled by singular, often limited strategies.
Jennifer M Fitzpatrick, Emily Peak, Samirah Perally, Iain W Chalmers, John Barrett, Timothy P Yoshino, Alasdair C Ivens, Karl F Hoffmann   +7 more
doaj   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source