Results 61 to 70 of about 977,147 (296)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sparse Total Focus Imaging of Rail Transit Rail Defects Based on Grey Wolf Algorithm

Chengshi guidao jiaotong yanjiu
[Objective] Using the ultrasonic phased array technology can realize high-precision imaging detection of rail transit rail defects. However, the widely used FMC-TFM (full matrix capture-total focusing method) has the disadvantages of long computation ...
Lubin QIAN, Hongbo WU, Chunxiang GAO, Zhengbo WEI, Yuhui XING   +4 more
doaj   +1 more source

Extending MCAS to hypernuclei and radiative-capture reactions

EPJ Web of Conferences, 2010
Using a Multi-Channel Algebraic Scattering (MCAS) approach we have analyzed the spectra of two hypernuclear systems, 9ΛBe and 13ΛC. We have studied the splitting of the two odd-parity excited levels (1/2− and 3/2−) at 11 MeV excitation in 13ΛC ...
Svenne J.P., Karataglidis S., Canton L., Amos K.   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Theoretical methods to treat a single dissipative bosonic mode coupled globally to an interacting many-body system

Physical Review Research, 2020
We present two approaches capable of describing the dynamics of an interacting many-body system on a lattice coupled globally to a dissipative bosonic mode.
Catalin-Mihai Halati, Ameneh Sheikhan, Corinna Kollath   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Link Prediction in Online Social Networks Based on the Unsupervised Marginalized Denoising Model

IEEE Access, 2019
As online social networking platforms change the ways and means of people communicating, accurate link prediction among a massive pool of users has become a difficult problem.
Zhangang Hao
doaj   +1 more source

Inferring chromosome radial organization from Hi-C data

BMC Bioinformatics, 2020
Background The nonrandom radial organization of eukaryotic chromosome territories (CTs) inside the nucleus plays an important role in nuclear functional compartmentalization. Increasingly, chromosome conformation capture (Hi-C) based approaches are being
Priyojit Das, Tongye Shen, Rachel Patton McCord   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source