Results 61 to 70 of about 225,172 (252)

Wavefront shaping simulations with augmented partial factorization

JPhys Photonics
Wavefront shaping can tailor multipath interference to control multiple scattering of waves in complex optical systems. However, full-wave simulations that capture multiple scattering are computationally demanding given the large system size and the ...
Ho-Chun Lin, Zeyu Wang, Chia Wei Hsu
doaj   +1 more source

Missing signposts on the roadmap to quality: a call to improve medication adherence indicators in data collection for population research

Frontiers in Pharmacology, 2013
Purpose: Poor adherence to prescribed medicines is associated with increased rates of poor outcomes, including hospitalization, serious adverse events, and death, and is also associated with increased healthcare costs.
Bradi B. Granger, Shelley A. Rusincovitch, Suzanne eAvery, Bryan C. Batch, Ashley A. Dunham, Mark N. Feinglos, Katherine eKelly, Marjorie ePierre-Louis, Susan E. Spratt, Robert M. Califf   +9 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Deformable Convolutional Matrix Factorization for Document Context-Aware Recommendation in Social Networks

IEEE Access, 2019
The extreme sparsity of the rating data seriously affects the recommendation quality of the recommendation system. In order to alleviate the problem of data sparsity, some convolutional neural network (CNN)-based models make full use of text data to ...
Honglong Chen, Jinnan Fu, Lei Zhang, Shuai Wang, Kai Lin, Leyi Shi, Lianhai Wang   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Optimal Design of Sparse Matrix Phased Array Using Simulated Annealing for Volumetric Ultrasonic Imaging with Total Focusing Method

Sensors
The total focusing method (TFM) is often considered to be the ‘gold standard’ for ultrasonic imaging in the field of nondestructive testing. The use of matrix phased arrays as probes allows for high-resolution volumetric TFM imaging.
Dmitry Olegovich Dolmatov, Vadim Yurevich Zhvyrblya   +1 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Binary system modes of matrix-coupled multidimensional oscillators

New Journal of Physics
The standard Kuramoto model has been instrumental in explaining synchronization and desynchronization, two emergent phenomena often observed in biological, neuronal, and physical systems.
Chongzhi Wang, Haibin Shao, Ying Tan, Dewei Li   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source