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Chemical Transformation of Hydrolyzed Fumonisin B1 to Hydrolyzed Fumonisin B2
Journal of Agricultural and Food Chemistry, 1995The fumonisins, a series of sphingosine-analog mycotoxins produced by the ubiquitous corn contaminant Fusarium moniliforme, are an important food safety concern because they are tumor promoters with sufficient chemical stability to persist through normal food processing.
Farid A. Badria +2 more
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Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents
Food and Chemical Toxicology, 2012The mycotoxin fumonisin B1 (FB1) is an important contaminant of maize and maize-based products. In rodent toxicity studies, FB1 was shown to be hepato- and nephrotoxic, and to induce renal tumors in rats when administered via the diet. Of particular note are the aggressive growth characteristics of FB1-induced tumors with a high potential to ...
Stephanie, Müller +2 more
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Synthesis of analogs of fumonisin B1
Journal of Agricultural and Food Chemistry, 1992The fungus Fusarium moniliforme Sheldon is one of the most important ear rot pathogens of corn (Nyvall, 1983). The toxicity of the mold was initially discovered when an isolate of F. moniliforme from corn grown in an area of Africa with a high incidence of esophageal cancer was tested (Marasas et al., 1981).
Kraus, George +2 more
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Fumonisin B1-Immunological EffectsS
1996Fumonisin B1 (FBI) (C34H59N015, Mol.wt.721) is classified as a Fusarium mycotoxin produced by some related species including F.moniliforme, F.proliferatum, F.anthophi-lum, F.dlamini, F.napiforme, and F.nygamai. These strains have been isolated in Australia, Austria, Brazil, Canada, China, Indonesia, Italy, Nepal, New Caledonia, Peru, the Philippines ...
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Antinutritional effects of fumonisin B1 and pathophysiological consequences
Toxicology Letters, 2003Due to its structural similarity with sphingosine, fumonisin B(1) (FB(1)) inhibits ceramide synthase (a key enzyme of sphingolipid biosynthesis) leading to an intracellular accumulation of sphingoid bases with a consequent increase of sphinganine/sphingosine (SA/SO) ratio. In adult male rats, dietary exposure to fumonisin induces a significant increase
CARRATU' M. R +4 more
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Residue formation of fumonisin B1 in porcine tissues
Food Additives and Contaminants, 2003The residues derived from the uptake of fumonisin B1, a toxic metabolite of Fusarium verticillioides frequently occurring in corn and corn products, were determined in growing pigs. After oral administration of 100 mg FB(1)/animal/day for 5-11 days, serum, bile, lung, liver, kidney, brain, spleen, pancreas, heart, muscle, eye, and fat samples were ...
K, Meyer +4 more
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Fumonisin B1 Toxicity in Male Sprague-Dawley Rats
1996Male rats were gavaged with fumonisin B1 (FB1) once daily for 11 consecutive days at doses of 0, 1, 5, 15, 35, and 75 mg FB1/kg body weight. Urine osmolality (at 5-75 mg FB1/kg) and organic ion transport in kidney slices (at 5-75 mg FB1/kg) were reduced.
G, Bondy +8 more
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Early toxic effects of fumonisin B1 in rat liver
Human & Experimental Toxicology, 2008Mycotoxin fumonisin B1 (FB1) is hepatotoxic and carcinogenic in experimental animals. It is known that long-term exposure of experimental animals to FB1 causes apoptosis and lipid peroxidation. In this study, male adult Wistar rats were treated with single FB1 doses (5, 50, and 500 μg/kg b.w.) and sacrificed 4, 24, and 48 hours after treatment ...
Domijan, Ana-Marija +7 more
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In Vitro Metabolism of Fumonisin B1 by Ruminal Microflora
Veterinary Research Communications, 2000Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium moniliforme and F. proliferatum. Little is known of its metabolic fate after oral ingestion in ruminants, but these animals are reported to be tolerant towards FB1. The metabolism of this mycotoxin was evaluated following incubation (1 microg/ml) in ruminal fluid for up to 72 h, in the presence or ...
Caloni, F. +5 more
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