Results 51 to 60 of about 11,568 (285)

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences [PDF]

, 2013
Fragments of prostatic acid phosphatase (PAP248-286) in human semen dramatically increase HIV infection efficiency by increasing virus adhesion to target cells.
Apostol, Arnold, Auer, Barnhart, Cabaleiro-Lago, Capule, Cegelski, Chien, Cloe, Cohen, Colletier, Dobson, Dzwolak, Eisenberg, Foo, Gerard, Gervaix, Giehm, Hammer, Han, Hauber, Hinz, Horvath, Jarrett, Jordal, Kim, Knowles, Krebs, Linse, Little, Ma, MacPhee, Manzoni, Martellini, Miklossy, Miklossy, Morales, Munch, Naiki, Olsen, Olsen, Olzscha, Ono, O’Nuallain, Padrick, Perelson, Pronchik, Rajan, Roan, Roan, Roan, Sawaya, Siddiqua, Suzuki, Thomas, Thurman, Tukel, Wang, Wang, Wasmer, Westermark, Wiltzius, Wurm, Xue, Yagi, Ye, Yin, Yu   +67 more
core   +1 more source

Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease. [PDF]

, 2016
The misfolding and self-assembly of intrinsically disordered proteins into insoluble amyloid structures are central to many neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.
Kaminski Schierle, Gabriele S, Kaminski, Clemens F   +1 more
core   +2 more sources

Thyroid function tests in amyloid goitre [PDF]

Postgraduate Medical Journal, 1990
Summary We present two patients with amyloid goitre due to primary systemic amyloidosis which was confirmed at post-mortem. Both were clinically euthyroid but had hyperthyroxinaemia and other thyroid function tests suggestive of thyrotoxicosis.
P, Duhra, J, Cassar
openaire   +2 more sources

Functional Coating from Amyloid Superwetting Films

Advanced Materials, 2022
AbstractTailoring the hydrophilicity of solid surfaces with a strong affinity to water has been extensively explored in the last 20 years, but studies have been limited to the single function of wettability. Here, the multifunctional properties of tailored surface films are extended from exhibiting superwettability to facilitating biological activities.
Tonghui Jin, Mohammad Peydayesh, Mingqin Li, Yang Yao, Di Wu, Raffaele Mezzenga   +5 more
openaire   +3 more sources

Periodontitis, microbiomes and their role in Alzheimer’s disease [PDF]

, 2017
As far back as the eighteenth and early nineteenth centuries, microbial infections were responsible for vast numbers of deaths. The trend reversed with the introduction of antibiotics coinciding with longer life.
Crean, Stjohn, Olsen, Ingar, Pritchard, Anna, Singhrao, Simarjit Kaur   +3 more
core   +2 more sources

Segmental Polymorphism in a Functional Amyloid [PDF]

Biophysical Journal, 2011
Although amyloid fibrils are generally considered to be causative or contributing agents in amyloid diseases, several amyloid fibrils are also believed to have biological functions. Among these are fibrils formed by Pmel17 within melanosomes, which act as a template for melanin deposition. We use solid-state NMR to show that the molecular structures of
Hu, Kan-Nian, McGlinchey, Ryan P., Wickner, Reed B., Tycko, Robert   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]

, 2017
Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi, Brahmachari, Sayanti, Bychenko, Darya, DeGrado, William F, Gazit, Ehud, Kolusheva, Sofiya, Mensa, Bruk, Schmidt, Nathan W, Schnaider, Lee, Shaham-Niv, Shira, Shimon, Linda JW   +10 more
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source