Results 21 to 30 of about 258,860 (206)

Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation

iScience, 2021
Summary: ERK1c is an alternatively spliced isoform of ERK1 that specifically regulates mitotic Golgi fragmentation, which allows division of the Golgi during mitosis.
Inbal Wortzel, Galia Maik-Rachline, Suresh Singh Yadav, Tamar Hanoch, Rony Seger   +4 more
doaj   +1 more source

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

iScience, 2021
Summary: Exosomes are important for cell–cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1, increase the dihydroceramide-to-ceramide ratio and cause hypomyelinating leukodystrophy. However, the disease mechanism remains
Chen-Yi Wu, Jhih-Gang Jhang, Wan-Syuan Lin, Pei-Huan Chuang, Chih-Wei Lin, Li-An Chu, Ann-Shyn Chiang, Han-Chen Ho, Chih-Chiang Chan, Shu-Yi Huang   +9 more
doaj   +1 more source

Early satellite cell communication creates a permissive environment for long-term muscle growth

iScience, 2021
Summary: Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal ...
Kevin A. Murach, Bailey D. Peck, Robert A. Policastro, Ivan J. Vechetti, Douglas W. Van Pelt, Cory M. Dungan, Lance T. Denes, Xu Fu, Camille R. Brightwell, Gabriel E. Zentner, Esther E. Dupont-Versteegden, Christopher I. Richards, Jeramiah J. Smith, Christopher S. Fry, John J. McCarthy, Charlotte A. Peterson   +15 more
doaj   +1 more source

Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis

International Journal of Molecular Sciences, 2022
Atherosclerosis is one of the key problems of modern medicine, which is due to the high prevalence of atherosclerotic cardiovascular diseases and their significant share in the structure of morbidity and mortality in many countries. Atherogenesis is a complex chain of events that proceeds over many years in the vascular wall with the participation of ...
openaire   +2 more sources

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

iScience, 2022
Summary: IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428 ...
Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook   +7 more
doaj   +1 more source

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

iScience, 2022
Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato, Moeko Sakai, Anna Ishii, Kaori Maehata, Yuki Takada, Kyota Yasuda, Tomoya Kotani   +6 more
doaj   +1 more source

Human Merkel cells – aspects of cell biology, distribution and functions

European Journal of Cell Biology, 2005
Human Merkel cells were first described by Friedrich S. Merkel in 1875 and named "Tastzellen" (touch cells) assuming a sensory touch function within the skin. Only ultrastructural research revealed their characteristics such as dense-core granules, plasma membrane spines and dendrites as well as a loosely arranged cytoskeleton.
Ingrid Moll, Marion Roessler, Johanna M. Brandner, Pia Houdek, Roland Moll, Ann-Christin Eispert   +5 more
openaire   +2 more sources

Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release

iScience, 2020
Summary: The ability of propionate, a short-chain fatty acid produced from the fermentation of non-digestible carbohydrates in the colon, to stimulate the release of anorectic gut hormones, such as glucagon like peptide-1 (GLP-1), is an attractive ...
Natarin Caengprasath, Noemi Gonzalez-Abuin, Maria Shchepinova, Yue Ma, Asuka Inoue, Edward W. Tate, Gary Frost, Aylin C. Hanyaloglu   +7 more
doaj   +1 more source

Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate

iScience, 2021
Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer ...
Liang Guo, Kan Zhu, Michael Pargett, Adam Contreras, Patrick Tsai, Quan Qing, Wolfgang Losert, John Albeck, Min Zhao   +8 more
doaj   +1 more source

Contribution of septins to human platelet structure and function

iScience, 2022
Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim, Rustem I. Litvinov, Elmira R. Mordakhanova, Erfei Bi, Olga Vagin, John W. Weisel   +5 more
doaj   +1 more source