Results 81 to 90 of about 155,433 (279)
Advancing HBV Diagnostics: The Role of Ultrasensitive HBsAg Testing
DiagnosticsHepatitis B virus (HBV) represents a significant global health challenge, affecting over 254 million individuals and contributing to 1.1 million deaths from liver-related complications in 2022.
Hussain Ali +2 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Frontiers in ImmunologyIntroductionPrevalence of chronic hepatitis B virus (HBV) infection remains a major global health issue. Research into a cure has focused on finite combinatorial interventions that aim to reduce HBV surface antigen (HBsAg), suppress virus specific immune
Gavin Lewis +7 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Laser-induced curing of functional polymers [PDF]
Designed Monomers and Polymers, 1998 Abstraet-Telechelic oligomers and polymers have been cross-linked within milliseconds upon exposure to a UV laser beam in the presence of a photoinitiator. The polymerization reaction was followed in real-time by infrared spectroscopy and was shown to proceed with long kinetic chains (up to 20000 functional groups polymerized per initiating radical ...
openaire +1 more source
Direct-acting antivirals and viral RNA targeting for hepatitis B cure
, 2020 International audiencePurpose of review: The current aim in the HBV landscape is to develop therapeutic strategies to achieve a functional cure of infection, characterized by a sustained loss of HBsAg off-treatment.
Janine French +5 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
IR radiation cure studies of Bi-functional epoxy resin systems [PDF]
, 2003 This report represents the I . radiation cure studies of Bi-functional Epoxy resin systems. Infrared Radiation is used to effect cross-linking reactions in two grades of bi-functional epoxy resin systems.
Rao, RMVGK, Rao, Sandhya
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source