Results 81 to 90 of about 3,358,253 (225)

Chronic Hepatitis B: Current Management and Future Directions

Diseases
Chronic hepatitis B virus (HBV) infection remains a major global health burden, affecting millions and contributing significantly to liver-related morbidity and mortality.
Hamza Ertugrul, Esra Ekiz, Sibel Islak Mutcali, Veysel Tahan, Ebubekir Daglilar   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Challenges in the Vaccination of HIV-Infected Individuals

Vaccines
Vaccination of people living with an HIV infection (PLWH) remains a worldwide challenge. The reason is the heterogeneity of this group that comprises people with and without highly active retroviral treatment and varying degrees of immunosuppression.
Marta Sisteré-Oró, Roberto Güerri-Fernandez, Montserrat Plana, Gennady Bocharov, Andreas Meyerhans   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Therapeutic hepatitis B vaccine employing DNA prime – MVA boost scheme requires additional priming with recombinant HBsAg to elicit an adequate antibody response

Frontiers in Immunology
Therapeutic vaccines offer hope for a curative treatment of chronic hepatitis B virus (HBV) infection. We developed a therapeutic hepatitis B vaccine, TherVacB, which employs priming with adjuvanted HBV S (HBsAg) and Core antigens of a single genotype ...
Hélène A. Kerth, Hélène A. Kerth, Martin Kächele, Nikolas Müller, Swati Singh, Margaret Tulessin, Julia Sacherl, Edanur Ates Öz, Edanur Ates Öz, Jinpeng Su, Jinpeng Su, Romina Bester, Susanne Miko, Katja Steiger, Carolin Mogler, Dirk H. Busch, Dirk H. Busch, Jochen M. Wettengel, Jochen M. Wettengel, Ulrike Protzer, Ulrike Protzer, Anna D. Kosinska, Anna D. Kosinska   +22 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Novel digital droplet inverse PCR assay shows that natural clearance of hepatitis B infection is associated with fewer viral integrations

Emerging Microbes and Infections
Hepatitis B virus (HBV) DNA integration into the host cell genome is reportedly a major cause of liver cancer, and a source of hepatitis B surface antigen (HBsAg).
Dong Li, Vikki Ho, Chiao-Fang Teng, Hung-Wen Tsai, Yuanyuan Liu, Sarah Bae, Harout Ajoyan, Jochen M. Wettengel, Ulrike Protzer, Brian S. Gloss, Rebecca J. Rockett, Rafid Al Asady, Jane Li, Simon So, Jacob George, Mark W. Douglas, Thomas Tu   +16 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Functional cure of chronic hepatitis B – predictable?

EBioMedicine, 2021
Wolfram Gerlich
doaj   +1 more source

Mechanisms and management of pegylated interferon-α toxicity in chronic hepatitis B

Frontiers in Immunology
Pegylated interferon-α (PegIFN-α) is a cornerstone immunomodulatory therapy with the potential to achieve a functional cure for chronic hepatitis B (CHB).
Liya Zhu, Fei Peng, Dingfang Pi, Jinzhi Lu   +3 more
doaj   +1 more source