Results 91 to 100 of about 535,935 (302)

Influence of estimated training status on anti and pro-oxidant activity, nitrite concentration, and blood pressure in middle-aged and older women [PDF]

, 2017
The purpose of this study was to compare the association between anti and pro-oxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of
Amaral, Sandra L., Brito, Janaina de Oliveira, da Silva, Roberta F., De Angelis, Kátia, Dias, Danielle da Silva, Jacomini, André M., Llesuy, Susana Francisca, Monteiro, Henrique L., Zago, Anderson S.   +8 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Silesians in Texas and Upper Silesia: anthropometric, functional and physical activity characteristics

Anthropological Review, 2020
Anthropometric, functional and physical activity characteristics of contemporary adult descendants of Upper Silesian immigrants to Texas in the mid-19th century and current residents in Upper Silesia were compared.
Rożek-Piechura Krystyna, Ignasiak Zofia, Kurzaj Monika, Sławinska Teresa, Skrzek Anna, Kozieł Sławomir, Malina Robert M   +6 more
doaj   +1 more source

Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient [PDF]

, 2012
Peer reviewedPublisher ...
Andreatta, Matthew, Loudet, Olivier, Poormohammad Kiani, Seifollah, Robert, Thierry, Salt, David E, Simon, Matthieu, Trontin, Charlotte   +6 more
core   +6 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PHYSICAL ACTIVITY, FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN OLDER PEOPLE [PDF]

, 2008
Gerontological research has shown that there is a marked decline in health with age and an associated demand for expensive medical services (Shepard, 1993).
Bravo, Jorge, FOLGADO, HUGO, RAIMUNDO, ARMANDO, TOMÁS-CARUS, PABLO   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The evolution of complex gene regulation by low specificity binding sites

, 2012
Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B., Stewart, Alexander J.   +1 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Degeneracy: a design principle for achieving robustness and evolvability

, 2009
Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may also play a vital role in enabling the evolution of species.
Bender, Axel, Whitacre, James M
core   +1 more source