Results 21 to 30 of about 2,588,001 (311)
Signal Transduction and Targeted Therapy, 2022 B cells secreting IL-10 functionally are recognized as functional regulatory B (Breg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting Breg cells in humans is still lacking ...
Xu-Yan Wang +14 more
doaj +1 more source
Two Amphioxus ApeC-Containing Proteins Bind to Microbes and Inhibit the TRAF6 Pathway
Frontiers in Immunology, 2021 The apextrin C-terminal (ApeC) domain is a class of newly discovered protein domains with an origin dating back to prokaryotes. ApeC-containing proteins (ACPs) have been found in various marine and aquatic invertebrates, but their functions and the ...
Jin Li +19 more
doaj +1 more source
Functional Profiling of Transcription Factor Genes in Neurospora crassa. [PDF]
, 2017 Regulation of gene expression by DNA-binding transcription factors is essential for proper control of growth and development in all organisms. In this study, we annotate and characterize growth and developmental phenotypes for transcription factor genes ...
Bekman, Thomas +17 more
core +1 more source
eLife, 2021 The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates ...
Yujiao He +10 more
doaj +1 more source
CRISPR-TSKO : a technique for efficient mutagenesis in specific cell types, tissues, or organs in Arabidopsis [PDF]
, 2019 Detailed functional analyses of many fundamentally important plant genes via conventional loss-of-function approaches are impeded by the severe pleiotropic phenotypes resulting from these losses.
Andrade Buono, Rafael +9 more
core +1 more source
Smoking affects gene expression in blood of patients with ischemic stroke. [PDF]
, 2019 ObjectiveThough cigarette smoking (CS) is a well-known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients.MethodsWe recruited IS-current smokers (IS-SM), IS-never smokers (IS-NSM), control ...
Ander, Bradley P +6 more
core +2 more sources
Scientific Reports, 2017 Marek’s disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-
Jie Li +4 more
doaj +1 more source
Elevated CO2 and Warming Altered Grassland Microbial Communities in Soil Top-Layers. [PDF]
, 2018 As two central issues of global climate change, the continuous increase of both atmospheric CO2 concentrations and global temperature has profound effects on various terrestrial ecosystems.
Deng, Ye +10 more
core +4 more sources
Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function [PDF]
, 2020 Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene to the connectivity $k$ of the corresponding protein in the PPI networks ...
Cimini, Giulio +2 more
core +2 more sources
Association Analysis Techniques for Discovering Functional Modules from Microarray Data [PDF]
, 2008 An application of great interest in microarray data analysis is the identification of a group of genes that show very similar patterns of expression in a data set, and are expected to represent groups of genes that perform common/similar functions, also ...
Gaurav Pandey +3 more
core +2 more sources