Results 31 to 40 of about 2,594,564 (358)

High-precision mapping reveals rare N 6 -deoxyadenosine methylation in the mammalian genome

Cell Discovery, 2022
N 6-deoxyadenosine methylation (6mA) is the most widespread type of DNA modification in prokaryotes and is also abundantly distributed in some unicellular eukaryotes. However, 6mA levels are remarkably low in mammals.
Li-Qian Chen, Zhang Zhang, Hong-Xuan Chen, Jian-Fei Xi, Xue-Hong Liu, Dong-Zhao Ma, Yu-Hao Zhong, Wen Hui Ng, Tao Chen, Daniel W. Mak, Qi Chen, Yao-Qing Chen, Guan-Zheng Luo   +12 more
doaj   +1 more source

Analysis of Genetic Interaction Maps Reveals Functional Pleiotropy [PDF]

, 2008
Epistatic or genetic interactions, representing the effects of mutations on the phenotypes caused by other mutations, can be very helpful for uncovering functional relationships between genes.
Jack Greenblatt, James Vlasblom, Karen Ronen, Shoshana J. Wodak, Shuye Pu   +4 more
core   +2 more sources

Identification and Transcriptomic Analyses of Two Endophytic Fungi WDR2 and WDR5 from Wild Soybean Elucidates Mechanistic Aspects of Alkali Stress Tolerance

Journal of Fungi
Soil alkalinization constitutes a significant abiotic stress factor that severely constrains global agricultural productivity. The application of alkali-tolerant endophytes represents a promising strategy for enhancing crop resilience. This study focused
Jiali Tian, Xuan Liu, Shixi Lu, Xuan Dong, Yujie Chen, Siqi Hou, Tianyu Lei, Xinyu Li, Ruixin Cao, Yue Su, Xiaodong Ding, Qiang Li, Jialei Xiao   +12 more
doaj   +1 more source

Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy [PDF]

, 2018
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes ...
Angelico F, Angeloni A, Arca M, Bailetti D, Baratta F, Belardinilli F, Ceci F, D'Erasmo L, De Masi B, Del Ben M, Di Costanzo A, Giannini G, Girelli G, Montali A, Pastori D, Polimeni L, Sponziello M   +16 more
core   +1 more source

Transcriptome and Physio-Biochemical Profiling Reveals Differentially Expressed Genes in Seedlings from Aerial and Subterranean Seeds Subjected to Drought Stress in Amphicarpaea edgeworthii Benth

Agronomy
Drought stress represents a prevalent environmental challenge that significantly impedes plant growth. The Chinese hog-peanut (Amphicarpaea edgeworthii Benth.), an amphicarpic legume, can produce both aerial seeds (ASs) and subterranean seeds (SSs ...
Jiancheng Kou, Yue Su, Tianyu Lei, Siqi Hou, Jiali Tian, Minglong Li, Shuzhen Zhang, Xiaodong Ding, Qiang Li, Jialei Xiao   +9 more
doaj   +1 more source

Cell Cycle Regulation by Alternative Polyadenylation of CCND1

Scientific Reports, 2018
Global shortening of 3′UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown.
Qiong Wang, Guopei He, Mengmeng Hou, Liutao Chen, Shangwu Chen, Anlong Xu, Yonggui Fu   +6 more
doaj   +1 more source

The Functional Consequences of Variation in Transcription Factor Binding

, 2013
One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in ...
Cusanovich, Darren A., Gilad, Yoav, Pavlovic, Bryan, Pritchard, Jonathan K.   +3 more
core   +3 more sources

Coordinated functional divergence of genes after genome duplication in Arabidopsis thaliana [PDF]

, 2017
Gene and genome duplications have been rampant during the evolution of flowering plants. Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy entire pathways or networks, and as such create the unique situation in which such ...
De Smet, Riet, Li, Zhen, Sabaghian, Ehsan, Saeys, Yvan, Van de Peer, Yves   +4 more
core   +1 more source

DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS

Frontiers in Immunology, 2019
DExD/H-box helicases play essential roles in RNA metabolism, and emerging data suggests that they have additional functions in antiviral immunity across species.
Jie Ruan, Yange Cao, Tao Ling, Peiyi Li, Shengpeng Wu, Dezhi Peng, Yao Wang, Xin Jia, Shangwu Chen, Anlong Xu, Anlong Xu, Shaochun Yuan, Shaochun Yuan   +12 more
doaj   +1 more source

Epitranscriptomic subtyping, visualization, and denoising by global motif visualization

Nature Communications, 2023
Advances in sequencing technologies have empowered epitranscriptomic profiling at the single-base resolution. Putative RNA modification sites identified from a single high-throughput experiment may contain one type of modification deposited by different ...
Jianheng Liu, Tao Huang, Jing Yao, Tianxuan Zhao, Yusen Zhang, Rui Zhang   +5 more
doaj   +1 more source