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Screening Approaches to Neurotoxicity: A Functional Observational Battery
Journal of the American College of Toxicology, 1989Observational tests to assess the behavioral and neurologic integrity of laboratory rats have been advanced for use in the primary screening of chemicals to detect neurotoxic potential. To examine the use of such an approach, we are systematically using a functional observational battery (FOB) to characterize known neurotoxicants and to assess its ...
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CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology
2015This chapter describes various approaches for the preclinical assessment of drug-induced central nervous system (CNS) adverse effects. Traditionally, methods to evaluate CNS effects have consisted of observing and scoring behavioral responses of animals after drug is administered. Among several behavioral testing paradigms, the Irwin and the functional
Carlos, Fonck +3 more
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Approaches for assessing the validity of a functional observational battery
Neurotoxicology and Teratology, 1990As neurobehavioral assessments during the preliminary stages of chemical testing are more widely undertaken, it is critical that the screening procedures utilized be valid indicators of neurobehavioral function and that they be sensitive, specific, and reliable.
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Toxicology and Applied Pharmacology, 1991
A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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Fundamental and Applied Toxicology, 1994
The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
J S, Tegeris, R L, Balster
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The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
J S, Tegeris, R L, Balster
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Journal of Pharmacological and Toxicological Methods, 2009
The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
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The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
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Journal of Pharmacological and Toxicological Methods, 2016
The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man".
David V, Gauvin +7 more
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The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man".
David V, Gauvin +7 more
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Toxicology and Applied Pharmacology, 2005
Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Nicole, Hübler +4 more
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Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Nicole, Hübler +4 more
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Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice
Journal of Medicinal FoodThis study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental mice were randomly assigned to four groups (n = 8 per group) and received intravenous caffeine at a dose of 0, 5, 10, or 20 mg/kg.
Sung-Hyun Cho +3 more
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Design of Functional Interval Observers for a Battery and Motor Circuit Model of Electric Vehicle
2019 IEEE Vehicle Power and Propulsion Conference (VPPC), 2019In this paper we first establish a model of battery and motor circuit for electric vehicle (EV). We then consider the problem of estimating linear functions of the state vector of this model. We design two novel observers to estimate the set of admissible values for linear functions of the state vector at each instant of time.
Dinh Cong Huong +2 more
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