Results 41 to 50 of about 549 (211)

Development of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy

Nature Communications
The metal-nucleic acid nanocomposites, first termed metal-nucleic acid frameworks (MNFs) in this work, show extraordinary potential as functional nanomaterials.
Jiaqi Yan, Rajendra Bhadane, Meixin Ran, Xiaodong Ma, Yuanqiang Li, Dongdong Zheng, Outi M. H. Salo-Ahen, Hongbo Zhang   +7 more
doaj   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

High-throughput site-directed mutagenesis using oligonucleotides synthesized on DNA chips

BioTechniques, 2005
Site-directed mutagenesis has greatly helped researchers both to understand the precise role of specific residues in coding sequences and to generate variants of proteins that have acquired new characteristics.
Didier Saboulard, Vincent Dugas, Mehdi Jaber, Jérôme Broutin, Eliane Souteyrand, Julien Sylvestre, Marc Delcourt   +6 more
doaj   +1 more source

Stable gene targeting in human cells using single-strand oligonucleotides with modified bases. [PDF]

PLoS ONE, 2012
Recent advances allow multiplexed genome engineering in E. coli, employing easily designed oligonucleotides to edit multiple loci simultaneously. A similar technology in human cells would greatly expedite functional genomics, both by enhancing our ...
Xavier Rios, Adrian W Briggs, Danos Christodoulou, Josh M Gorham, Jonathan G Seidman, George M Church   +5 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

RNAi methodologies for the functional study of signaling molecules. [PDF]

PLoS ONE, 2009
RNA interference (RNAi) was investigated with the aim of achieving gene silencing with diverse RNAi platforms that include small interfering RNA (siRNA), short hairpin RNA (shRNA) and antisense oligonucleotides (ASO).
Gwang Lee, Leah A Santat, Mi Sook Chang, Sangdun Choi   +3 more
doaj   +1 more source

Fluorescent Nanosensor for Indole‐3‐Propionic Acid Detection in Gut Health Monitoring

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
This work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Mervin Chun‐Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez‐Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S. Strano   +15 more
wiley   +1 more source

Recent developments in reversible photoregulation of oligonucleotide structure and function [PDF]

Chemical Society Reviews, 2017
A critical overview is given of recent applications of molecular photoswitches to modulate DNA and RNA structure and function.
Anouk S. Lubbe, Wiktor Szymanski, Ben L. Feringa   +2 more
openaire   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source