Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]
, 2014 The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John +5 more
core +1 more source
Melanin Induction Restores the Pathogenicity of Gaeumannomyces graminis var. tritici in Wheat Plants
Journal of Fungi, 2023 One of the most challenging aspects of long-term research based on microorganisms is the maintenance of isolates under ex situ conditions, particularly the conservation of phytopathological characteristics.
Camila Aranda +7 more
doaj +1 more source
Targeted disruption of melanin biosynthesis genes in the human pathogenic fungus Lomentospora prolificans and its consequences for pathogen survival [PDF]
, 2016 PublishedArticleThe dematiaceous (melanised) fungus Lomentospora (Scedosporium) prolificans is a life-threatening opportunistic pathogen of immunocompromised humans, resistant to anti-fungal drugs. Melanin has been shown to protect human pathogenic fungi
Al-Laaeiby, Ayat +3 more
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Galleria mellonella immune melanization is fungicidal during infection
Communications Biology, 2022 Real-time imaging of fungal infection and tissue clearing in the wax moth, Galleria mellonella, help evaluate the role of melanin in the insect host immune response to fungal pathogens.
Daniel F. Q. Smith +4 more
doaj +1 more source
Extraction and virulence analysis of melanin from Fonsecaea monophora
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To construct a mouse model of footpad inoculation with Fonsecaea monophora (F.monophora) melanin, and to analyze the differences in the virulence of F.monophora melanin from different sources.
Huan HUANG +8 more
doaj +1 more source
Modeling Fungal Melanin Buildup: Biomimetic Polymerization of 1,8-Dihydroxynaphthalene Mapped by Mass Spectrometry [PDF]
, 2017 Due to the emerging biomedical relevance and technological potential of fungal melanins, and prompted by the virtual lack of information about their structural arrangement, an optimized synthetic protocol has been devised for a potential structural model
Barnes +28 more
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Frontiers in Fungal BiologyIntroducionFungal melanin is an underexplored natural biomaterial of great biotechnological interest in different areas. This study investigated the physical, chemical, electrochemical, and metal-binding properties of melanin extracted from the ...
Cristy Medina-Armijo +7 more
doaj +1 more source
Journal of Fungi, 2023 Fungal pigments, including melanin, are recognized as promising materials for biomedical, environmental, and technological applications. In previous studies, we have demonstrated that the DOPA-melanin produced by the MEL1 mutant of Aspergillus nidulans ...
Beatriz Silva Campanhol +4 more
doaj +1 more source
Activation of the Alternative Complement Pathway by Fungal Melanins [PDF]
Clinical and Vaccine Immunology, 2002 ABSTRACTMelanins are complex biological pigments formed by the oxidative polymerization of phenolic and/or indolic compounds. These pigments have been implicated in the pathogenesis of some microbial infections, malignancies, degenerative disorders, and autoimmune diseases.
A L, Rosas +4 more
openaire +2 more sources
An initial event in insect innate immune response: structural and biological studies of interactions between β-1,3-glucan and the N-terminal domain of β-1,3-glucan recognition protein [PDF]
, 2013 In response to invading microorganisms, insect β-1,3-glucan recognition protein (βGRP), a soluble receptor in the hemolymph, binds to the surfaces of bacteria and fungi and activates serine protease cascades that promote destruction of pathogens by means
Amzel L. M. +45 more
core +2 more sources