Furanocoumarins from Ruta chalepensis with Amebicide Activity [PDF]
Molecules, 2021 Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries.
A. F. Bazaldúa-Rodríguez +5 more
semanticscholar +5 more sources
Heracleum sosnowskyi Manden. in the Context of Sustainable Development: An Aggressive Invasive Species with Potential for Utilisation in the Extraction of Furanocoumarins and Essential Oils [PDF]
Journal of XenobioticsHeracleum sosnowskyi Manden., or H. sosnowskyi, of the Apiaceae was first cultivated in the USSR in 1947 as a potential fodder plant. Due to the development of cold-resistant cultivars and the characteristics of H. sosnowskyi, it quickly became feral. As
Ekaterina Sergeevna Osipova +2 more
doaj +2 more sources
Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]
Clin Pharmacol TherGrapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Aurinsalo L +7 more
europepmc +2 more sources
Analysis of the Toxicological Profile of Heracleum sosnowskyi Manden. Metabolites Using In Silico Methods [PDF]
PlantsThe invasive plant Heracleum sosnowskyi Manden. is a valuable source of a number of bioactive metabolites that can be used in the pharmaceutical industry and medicine and may have some other applications as well.
Anna E. Rassabina, Maxim V. Fedorov
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Extraction, Isolation, and Purification of Furanocoumarins from Invasive Heracleum sosnowskyi
SeparationsHeracleum sosnowskyi Manden. (Sosnowsky’s hogweed), originally introduced to Central and Eastern Europe as a fodder crop, has become a highly invasive species due to its ecological adaptability, high reproductive capacity, and efficient seed dispersal ...
Vida Vickackaite +2 more
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Molecules, 2019 The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for ...
Renato Bruni +9 more
doaj +2 more sources
Causes of delayed angiosperm diversification: The photosynthetic revolution, increased opportunity costs of anti-herbivore defenses, selection for qualitative toxins, and acceleration of plant-herbivore coevolution. [PDF]
Am J BotAbstract Why did it take so long for angiosperms to diversify after they arose? Here I consider the indirect but potentially crucial impact of the “photosynthetic revolution” on plant–herbivore coevolution. Increased vein density in fossil leaves implies a doubling in photosynthesis 125–100 million years ago.
Givnish TJ.
europepmc +2 more sources
New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants [PDF]
LifeThe present review explores the underlying mechanisms of phytophotodermatitis, a non-immunologic skin reaction triggered by certain plants followed by exposure to ultraviolet radiation emitted by sunlight.
Cristina Grosu (Dumitrescu) +8 more
doaj +2 more sources
Biological Activity Evaluation Against Fusarium oxysporum, Fusarium circinatum, and Meloidogyne incognita of Bioactives-Enriched Extracts of Ruta graveolens L. [PDF]
MoleculesRuta graveolens L. has been described as possessing antifungal and nematicidal activity. Among the bioactive compounds present in this plant, alkaloids and furanocoumarins have attracted considerable attention.
Lorena Reyes-Vaquero +5 more
doaj +2 more sources
Assessment of the Intestinal CYP3A Contribution to Drug Interactions with Extended-Release Tacrolimus (LCPT) Using Grapefruit Juice. [PDF]
Clin Pharmacol Drug DevAbstract Grapefruit juice (GFJ) is a known inhibitor of intestinal cytochrome P450 3A (CYP3A) metabolism leading to increased exposure to CYP3A substrates such as tacrolimus. The extended‐release tacrolimus formulation Envarsus (LCPT) exhibits prolonged absorption throughout the entire GI tract.
Alabi A +7 more
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