Results 41 to 50 of about 4,257 (227)
Molecules, 2012 Coumarins are nowadays an important group of organic compounds from natural sources that are useful in a number of fields. Because they possess different pharmacological properties, finding the proper extraction conditions for their separation from plant
Krystyna Skalicka-Woźniak +1 more
doaj +1 more source
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice–felodipine interaction [PDF]
The American Journal of Clinical Nutrition, 2006 Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear.To ascertain whether ...
Mary F, Paine +8 more
openaire +2 more sources
Exploring Cheminformatic Toolsets for Predicting the Dermal Toxicity of Furanocoumarins
, 2021 Linear furanocoumarins are skin sensitizers and anticancer agents whose appeal in skincare therapeutics is widely exploited. Owing to the need to predict the biological activities of medicines, this work aimed the investigate the predicted dermal ...
Thomaz, Douglas Vieira +4 more
core +1 more source
Bioactive Compounds in Health and Disease, 2021 Background: The roots of Angelica dahurica Bentham et Hooker filius ex Franchet et Savatier (Apiaceae) have traditionally been used for inflammatory skin diseases. A.
Ryo Okada +9 more
semanticscholar +1 more source
Plants, 2022 Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, three Cachrys species from Southern Italy were investigated for both the phytochemical profile and the potential anti-inflammatory properties.
Maria Rosaria Perri +8 more
doaj +1 more source
Scientific Reports, 2019 Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc.
Reetuparna Acharya +4 more
semanticscholar +1 more source
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
Wei He, Hiroki Takezawa, Makoto Fujita
wiley +2 more sources
Convergent evolution leading to the appearance of furanocoumarins in citrus plants.
Plant Science, 2020 Furanocoumarins are defense molecules mainly described in four plant families that are phylogenetically distant. Molecular characterization of the biosynthetic pathway has been started for many years in Apiaceae and Rutaceae.
Mariana Limones-Mendez +7 more
semanticscholar +1 more source
Molecules, 2020 Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells.
Fatma Tosun +4 more
doaj +1 more source
Gut Metabolism of Furanocoumarins: Proposed Function of Co O-Methyltransferase
ACS Omega, 2020 Gut metabolism of natural products is of great interest due to the altered biological activity of the metabolites. To study the gut metabolism of the dietary furanocoumarins, the biotransformation of Angelica dahurica was studied with human gut ...
S. Tan, B. Eser, Jaehong Han
semanticscholar +1 more source