Results 31 to 40 of about 2,649 (197)

Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences

Molecules, 2022
Imperatorin, a naturally derived furanocoumarin, exerts promising neuropharmacological properties. Therefore, it might be applicable in the treatment of brain diseases such as depression.
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Woźniak, Barbara Budzyńska   +6 more
doaj   +1 more source

Phytochemical Profile and In Vitro Antioxidant and Photobiological Properties of Different Extracts from Prangos ferulacea Lindl.

Antioxidants, 2023
Interesting photobiological properties have been demonstrated for some Cachrys species, including C. libanotis L., C. sicula L., and C. pungens Jan. The present study was designed to assess the photocytotoxic activity of Prangos ferulacea Lindl. (synonym
Mariangela Marrelli, Francesca Giordano, Maria Rosaria Perri, Valentina Amodeo, Noemi Baldino, Carmine Lupia, Dimitar Uzunov, Vincenzo Musolino, Filomena Conforti, Maria Luisa Panno   +9 more
doaj   +1 more source

Inhibitory Potential of Furanocoumarins Against Cyclin Dependent Kinase 4 Using Integrated Docking, MD and ONIOM Methods [PDF]

, 2023
Cyclin Dependent Kinase 4 (CDK4) is vital in the process of cell-cycle and serves as a G1 phase checkpoint in cell division. Selective antagonists of CDK4 which are in use as clinical chemotherapeutics cause various side-effects in patients ...
Moumita , Basumatary, Ramesh Chandra, Deka, Ambalika, Phonglo, Srutishree, Sarma, Dikshita, Dowerah   +4 more
core   +1 more source

Cytotoxic, Anti-Hemolytic, and Antioxidant Activities of Ruta chalepensis L. (Rutaceae) Extract, Fractions, and Isolated Compounds

Plants, 2023
Ruta chalepensis is an herb used to treat various ailments, and its potential cytotoxic effects on different tumor cell lines have been extensively studied. The present study aimed to evaluate the cytotoxic activity of R.
Joel H. Elizondo-Luévano, Nancy E. Rodríguez-Garza, Aldo F. Bazaldúa-Rodríguez, César I. Romo-Sáenz, Patricia Tamez-Guerra, María J. Verde-Star, Ricardo Gomez-Flores, Ramiro Quintanilla-Licea   +7 more
doaj   +1 more source

A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice–felodipine interaction [PDF]

The American Journal of Clinical Nutrition, 2006
Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear.To ascertain whether ...
Mary F, Paine, Wilbur W, Widmer, Heather L, Hart, Susan N, Pusek, Kimberly L, Beavers, Anne B, Criss, Sherri S, Brown, Brian F, Thomas, Paul B, Watkins   +8 more
openaire   +2 more sources

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Plants, 2021
Photochemotherapy is one of the most interesting current therapeutic approaches for the treatment of melanoma. Different classes of naturally occurring phytochemicals demonstrated interesting photoactive properties.
Mariangela Marrelli, Maria Rosaria Perri, Valentina Amodeo, Francesca Giordano, Giancarlo A. Statti, Maria Luisa Panno, Filomena Conforti   +6 more
doaj   +1 more source

Pressurized Liquid Extraction of Coumarins from Fruits of Heracleum leskowii with Application of Solvents with Different Polarity under Increasing Temperature

Molecules, 2012
Coumarins are nowadays an important group of organic compounds from natural sources that are useful in a number of fields. Because they possess different pharmacological properties, finding the proper extraction conditions for their separation from plant
Krystyna Skalicka-Woźniak, Kazimierz Głowniak   +1 more
doaj   +1 more source

Cachrys spp. from Southern Italy: Phytochemical Characterization and JAK/STAT Signaling Pathway Inhibition

Plants, 2022
Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, three Cachrys species from Southern Italy were investigated for both the phytochemical profile and the potential anti-inflammatory properties.
Maria Rosaria Perri, Michele Pellegrino, Stefano Aquaro, Fabiola Cavaliere, Carmine Lupia, Dimitar Uzunov, Mariangela Marrelli, Filomena Conforti, Giancarlo Statti   +8 more
doaj   +1 more source

Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

Molecules, 2020
Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells.
Fatma Tosun, Feyyaz Mıhoğlugil, John A. A. Beutler, Esra Eroğlu Özkan, Mahmut Miski   +4 more
doaj   +1 more source

Protein Sequestration of Lipophilic Furanocoumarins in Grapefruit Juice

, 2016
The sequestration of grapefruit furanocoumarins by foods was investigated by characterizing the binding between these compounds and foods with contrasting protein, fat, and carbohydrate compositions.
Jan A. Narciso (1999930), John A. Manthey (480106), Kyung Myung (1606687)   +2 more
core   +1 more source