Results 31 to 40 of about 4,257 (227)

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

Molecules, 2022
Despite significant advances in early diagnosis and treatment, cancer is one of the leading causes of death. Photodynamic therapy (PDT) is a therapy for the treatment of many diseases, including cancer.
Tomasz Piotr Kubrak, Przemysław Kołodziej, Jan Sawicki, Anna Mazur, Katarzyna Koziorowska, David Aebisher   +5 more
doaj   +1 more source

Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

Acta Pharmaceutica Sinica B, 2023
Pyran- and furanocoumarins are key representatives of tetrahydropyrans and tetrahydrofurans, respectively, exhibiting diverse physiological and medical bioactivities. However, the biosynthetic mechanisms for their core structures remain poorly understood.
Yucheng Zhao, Yuedong He, Liangliang Han, Libo Zhang, Yuanzheng Xia, Fucheng Yin, Xiaobing Wang, Deqing Zhao, Sheng Xu, Fei Qiao, Yibei Xiao, Lingyi Kong   +11 more
semanticscholar   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]

Clin Pharmacol Ther
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Aurinsalo L, Lapatto-Reiniluoto O, Kurkela M, Neuvonen M, Moilanen E, Niemi M, Tornio A, Backman JT.   +7 more
europepmc   +2 more sources

Evaluation of safety profile of the essential oils of eight Heracleum taxa (Apiaceae) related to determined furanocoumarin content [PDF]

Arhiv za farmaciju, 2019
For essential oils of roots, leaves, flowers and fruits of eight Heracleum taxa (H. sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicum subsp. pollinianum, H. pyrenaicum subsp. orsinii, H. verticillatum and H.
Ušjak Ljuboš, Drobac Milica, Niketić Marjan, Petrović Silvana   +3 more
doaj   +1 more source

Imperatorin as a Promising Chemotherapeutic Agent against Human Larynx Cancer and Rhabdomyosarcoma Cells

Molecules, 2020
Naturally occurring coumarins are bioactive compounds widely used in Asian traditional medicine. They have been shown to inhibit proliferation, induce apoptosis, and/or enhance the cytotoxicity of currently used drugs against a variety of cancer cell ...
Aneta Grabarska, Krystyna Skalicka-Woźniak, Michał Kiełbus, Magdalena Dmoszyńska-Graniczka, Paulina Miziak, Justyna Szumiło, Ewa Nowosadzka, Krystyna Kowalczuk, Sherief Khalifa, Jolanta Smok-Kalwat, Janusz Klatka, Krzysztof Kupisz, Krzysztof Polberg, Adolfo Rivero-Müller, Andrzej Stepulak   +14 more
doaj   +1 more source

Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences

Molecules, 2022
Imperatorin, a naturally derived furanocoumarin, exerts promising neuropharmacological properties. Therefore, it might be applicable in the treatment of brain diseases such as depression.
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Woźniak, Barbara Budzyńska   +6 more
doaj   +1 more source

Phytochemical Profile and In Vitro Antioxidant and Photobiological Properties of Different Extracts from Prangos ferulacea Lindl.

Antioxidants, 2023
Interesting photobiological properties have been demonstrated for some Cachrys species, including C. libanotis L., C. sicula L., and C. pungens Jan. The present study was designed to assess the photocytotoxic activity of Prangos ferulacea Lindl. (synonym
Mariangela Marrelli, Francesca Giordano, Maria Rosaria Perri, Valentina Amodeo, Noemi Baldino, Carmine Lupia, Dimitar Uzunov, Vincenzo Musolino, Filomena Conforti, Maria Luisa Panno   +9 more
doaj   +1 more source

Cytotoxic, Anti-Hemolytic, and Antioxidant Activities of Ruta chalepensis L. (Rutaceae) Extract, Fractions, and Isolated Compounds

Plants, 2023
Ruta chalepensis is an herb used to treat various ailments, and its potential cytotoxic effects on different tumor cell lines have been extensively studied. The present study aimed to evaluate the cytotoxic activity of R.
Joel H. Elizondo-Luévano, Nancy E. Rodríguez-Garza, Aldo F. Bazaldúa-Rodríguez, César I. Romo-Sáenz, Patricia Tamez-Guerra, María J. Verde-Star, Ricardo Gomez-Flores, Ramiro Quintanilla-Licea   +7 more
doaj   +1 more source

Furanocoumarins from Ruta chalepensis with Amebicide Activity

Molecules, 2021
Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries.
A. F. Bazaldúa-Rodríguez, R. Quintanilla-Licea, M. J. Verde-Star, M. Hernández-García, J. Vargas-Villarreal, J. N. Garza-González   +5 more
semanticscholar   +1 more source

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Plants, 2021
Photochemotherapy is one of the most interesting current therapeutic approaches for the treatment of melanoma. Different classes of naturally occurring phytochemicals demonstrated interesting photoactive properties.
Mariangela Marrelli, Maria Rosaria Perri, Valentina Amodeo, Francesca Giordano, Giancarlo A. Statti, Maria Luisa Panno, Filomena Conforti   +6 more
doaj   +1 more source