The Health Benefits of Grapefruit Furanocoumarins
EDIS, 2018 Although contraindicated for certain medications, grapefruits are also known for their numerous health benefits. Both these effects come from, in part, natural chemicals called furanocoumarin.
Yu Wang, Laura E. Reuss
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Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli [PDF]
Molecules, 2022 Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Joana L. Rodrigues +2 more
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Biological Activity Evaluation Against Fusarium oxysporum, Fusarium circinatum, and Meloidogyne incognita of Bioactives-Enriched Extracts of Ruta graveolens L. [PDF]
MoleculesRuta graveolens L. has been described as possessing antifungal and nematicidal activity. Among the bioactive compounds present in this plant, alkaloids and furanocoumarins have attracted considerable attention.
Lorena Reyes-Vaquero +5 more
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Biotransformation of furanocoumarins by Cunninghamella elegans
Bulletin of Faculty of Pharmacy Cairo University, 2015 Biotransformation of Furanocoumarins; psoralen (1), bergapten (2), xanthotoxin (3) and imperatorin (4) was explored by Cunninghamella elegans NRRL 1392, revealing the metabolism of psoralen (1) and bergapten (2) into bergaptol (5), while xanthotoxin (3 ...
Ghada Ismail El-shahat Ali Attia +2 more
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A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice–felodipine interaction [PDF]
American Journal of Clinical Nutrition, 2006 Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear.To ascertain whether ...
Mary F, Paine +8 more
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Characterization of Furanocoumarin Profile and Inheritance Toward Selection of Low Furanocoumarin Seedless Grapefruit Cultivars [PDF]
Journal of the American Society for Horticultural Science, 2011 Furanocoumarins are organic chemical components in grapefruit ( Citrus paradisi ) juice that have been shown to induce potentially deleterious drug interactions. In this study we measured seven furanocoumarins (FCs) [bergamottin, 6′,7′-dihydroxybergamottin (6,7-DHB), paradisin C, bergaptol ...
Chunxian Chen +3 more
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The Different Composition of Coumarins and Antibacterial Activity of Phlojodicarpus sibiricus and Phlojodicarpus villosus Root Extracts [PDF]
PlantsPhlojodicarpus sibiricus, a valuable endangered medicinal plant, is a source of angular pyranocoumarins used in pharmacology. Due to limited resource availability, other pyranocoumarin sources are needed. In the present research, the chemical composition
Maria T. Khandy +3 more
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Phytochemical characterisation of two news blood grapefruits by means of HPLC-MS
Food Chemistry Advances, 2022 In this study, the main flavanones, polymethoxyflavones, anthocyanins and furanocoumarins were evaluated in two blood grapefruits (CQP 31 and CQP 32), in their juice, peel, and leaves, by means of HPLC-DAD analysis and identified by HPLC-MS-MS.
José Antonio del Río +5 more
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Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]
Clin Pharmacol TherGrapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Aurinsalo L +7 more
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Oxypeucedanin: Chemotaxonomy, Isolation, and Bioactivities
Plants, 2021 The present review comprehensively gathered phytochemical, bioactivity, and pharmacokinetic reports on a linear furanocoumarin, namely oxypeucedanin. Oxypeucedanin (OP), which structurally contains an epoxide ring, has been majorly isolated from ethyl ...
Javad Mottaghipisheh
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