Results 1 to 10 of about 5,571 (175)

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi [PDF]

Frontiers in Cellular and Infection Microbiology, 2018
Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar, Derek Gatherer, Chandrajit Lahiri   +2 more
doaj   +9 more sources

Scientific Opinion on Flavouring Group Evaluation 75, Revision 1 (FGE.75Rev1): Consideration of tetrahydrofuran derivatives evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008) [PDF]

EFSA Journal, 2016
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) of the EFSA was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +2 more sources

3,4-Dihalo-5-hydroxy-2(5H)-furanones: Highly Reactive Small Molecules [PDF]

Molecules
3,4-Dichloro-5-hydroxy-2(5H)-furanone and its dibromo analog are highly reactive molecules. Both are members of the 2(5H)-furanone family, which are important as pharmacophores present in drugs and natural products.
Katarzyna Żurawska, Anna Byczek-Wyrostek, Anna Kasprzycka, Krzysztof Walczak   +3 more
doaj   +2 more sources

Molecular characterization and inhibition of cyclic-di-GMP receptor proteins in Pseudomonas aeruginosa: INSIGHTS from docking and dynamics studies [PDF]

Biochemistry and Biophysics Reports
The emergence of antibiotic-resistant Pseudomonas aeruginosa biofilms necessitates novel therapeutic strategies targeting virulence pathways. In this study the structural mechanisms underlying the differential anti-biofilm efficacy of epigallocatechin ...
Sinethemba H. Yakobi, Winnie Ramaloko, Nontuthuko E. Maningi   +2 more
doaj   +2 more sources

Scientific Opinion on Flavouring Group Evaluation 99 Revision 1 (FGE.99Rev1): Consideration of furanone derivatives evaluated by the JECFA (63rd, 65th and 69th meetings) [PDF]

EFSA Journal, 2015
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +2 more sources

Scientific opinion on Flavouring Group Evaluation 313, (FGE.313): α,β‐unsaturated 3(2H)‐furanone derivatives from chemical group 13 [PDF]

EFSA Journal, 2016
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of EFSA was requested to evaluate three flavouring substances, 2,5‐dimethyl‐4‐ethoxyfuran‐3(2H)‐one [FL‐no: 13.117], 2,5‐dimethylfuran‐3(2H)‐one [FL‐no: 13.119] and 4‐Acetyl‐2 ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +2 more sources

The nonvolatile and volatile substances changes based on non-target metabonomics reveals the formation mechanism of Tsamba flavor before and after roasting of highland barley [PDF]

Food Chemistry: X
As the traditional staple food for Tibetan people in northwest China, Tsamba is the main processing product of highland barley and roasting is the key processing step to determine the flavor of Tsamba.
Fang Wang, Yin-hua Ma, Hui-yang Xiong, Rui-jun Duan   +3 more
doaj   +2 more sources

The Novel Chiral 2(5H)-Furanone Sulfones Possessing Terpene Moiety: Synthesis and Biological Activity

Molecules, 2023
Over the past decades, 2(5H)-furanone derivatives have been extensively studied because of their promising ability to prevent the biofilm formation by various pathogenic bacteria.
Alsu M. Khabibrakhmanova, Roza G. Faizova, Olga A. Lodochnikova, Regina R. Zamalieva, Liliya Z. Latypova, Elena Y. Trizna, Andrey G. Porfiryev, Katsunori Tanaka, Oskar A. Sachenkov, Airat R. Kayumov, Almira R. Kurbangalieva   +10 more
doaj   +1 more source

Glycoconjugates of Mucochloric Acid—Synthesis and Biological Activity

Pharmaceuticals, 2023
The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry.
Katarzyna Żurawska, Daria Burdalska, Magdalena Skonieczna, Anna Byczek-Wyrostek, Anahit Dawicka, Anna Kasprzycka, Krzysztof Walczak   +6 more
doaj   +1 more source

Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation ...
Rania H. Abd El-Hameed, Shahenda Mahgoub, Hend M. El-Shanbaky, Mosaad S. Mohamed, Sahar A. Ali   +4 more
doaj   +1 more source