Molecules, 2020 The frequency of mycoses caused by drug-resistant fungal pathogen Candida albicans has increased drastically over the last two decades. The spread of drug-resistant strains, along with the limitations of currently available antifungals, complicates the ...
Irshad S. Sharafutdinov +8 more
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Thio Derivatives of 2(5H)-Furanone As Inhibitors against Bacillus subtilis Biofilms [PDF]
Acta Naturae, 2015 Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology.
Trizna E. +8 more
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Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar +2 more
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Natural Product Research, 2022 Three new compounds including one furanone, one morpholinone and one tetrahydrofuran together with three known compounds were isolated from the broth extract of the marine-derived fungus Talaromyces sp. PSU-MF07. The structures of the isolated compounds were determined on the basis of spectroscopic methods. The relative configuration was assigned using
Sucheewin Nuansri +5 more
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Oxidation of Chiral 2(5H)-Furanone Bis-Thioethers to Disulfoxides
Учёные записки Казанского университета: Серия Естественные науки, 2023 Novel disulfinyl derivatives based on 3,4-dichloro-2(5H)-furanone, aliphatic dithiols, and monoterpene alcohols were synthesized. Chiral bis-thioethers in the molecules of which the dithiol fragment links two five-membered cycles at C4 atoms were ...
A. M. Khabibrakhmanova +5 more
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Rapid Photodeactivation of Squaramide Chloride Transporters: A Tool for Cytotoxicity Modulation
ChemistryEuropeCytotoxic anion transporters with light‐regulation properties are highly interesting for the development of anticancer agents with reduced secondary effects.
Bartomeu Galmés +5 more
doaj +2 more sources
Synthesis of some furanone derivatives : putative quorum sensing or chitinase inhibitors [PDF]
, 2005 Bacteria are able to communicate through chemical signals. They can for instance estimate their population by the use of signalling compounds: this phenomenon is called quorum sensing. Some of these signalling compounds are derivatives of homoserine lactones.
Jolivet, Benoît
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Enzyme ribonucleotide reductase. The paradigm of enzyme inhibition by furanone derivatives [PDF]
Acta Crystallographica Section A: Foundations and Advances, 2005 Nuno M F S A Cerqueira
exaly +2 more sources
Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity [PDF]
Journal of Advanced Pharmacy Research, 2021 Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone
Mosad Mohamed +2 more
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Glycoconjugates of Mucochloric Acid—Synthesis and Biological Activity
Pharmaceuticals, 2023 The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry.
Katarzyna Żurawska +6 more
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