Results 1 to 10 of about 620,439 (167)

QSAR analysis of furanone derivatives as potential COX-2 inhibitors: kNN MFA approach [PDF]

Journal of Saudi Chemical Society, 2014
A series of thirty-two furanone derivatives with their cyclooxygenase-2 inhibitory activity were subjected to quantitative structural–activity relationship analysis to derive a correlation between biological activity as a dependent variable and various ...
Ruchi Bhatiya, Ankur Vaidya, Sushil K. Kashaw, Abhishek K. Jain, Ram K. Agrawal   +4 more
doaj   +4 more sources

The Novel Chiral 2(5H)-Furanone Sulfones Possessing Terpene Moiety: Synthesis and Biological Activity

Molecules, 2023
Over the past decades, 2(5H)-furanone derivatives have been extensively studied because of their promising ability to prevent the biofilm formation by various pathogenic bacteria.
Alsu M. Khabibrakhmanova, Roza G. Faizova, Olga A. Lodochnikova, Regina R. Zamalieva, Liliya Z. Latypova, Elena Y. Trizna, Andrey G. Porfiryev, Katsunori Tanaka, Oskar A. Sachenkov, Airat R. Kayumov, Almira R. Kurbangalieva   +10 more
doaj   +2 more sources

Increasing Susceptibility of Drug-Resistant Candida albicans to Fluconazole and Terbinafine by 2(5H)-Furanone Derivative

Molecules, 2020
The frequency of mycoses caused by drug-resistant fungal pathogen Candida albicans has increased drastically over the last two decades. The spread of drug-resistant strains, along with the limitations of currently available antifungals, complicates the ...
Irshad S. Sharafutdinov, Georgii D. Ozhegov, Alina E. Sabirova, Valentina V. Novikova, Svetlana A. Lisovskaya, Alsu M. Khabibrakhmanova, Almira R. Kurbangalieva, Mikhail I. Bogachev, Airat R. Kayumov   +8 more
doaj   +2 more sources

Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity [PDF]

Journal of Advanced Pharmacy Research, 2021
Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone
Mosad Mohamed, Rania Abd El-Hameed, Hend El-Shanbaky   +2 more
doaj   +1 more source

Glycoconjugates of Mucochloric Acid—Synthesis and Biological Activity

Pharmaceuticals, 2023
The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry.
Katarzyna Żurawska, Daria Burdalska, Magdalena Skonieczna, Anna Byczek-Wyrostek, Anahit Dawicka, Anna Kasprzycka, Krzysztof Walczak   +6 more
doaj   +1 more source

Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation ...
Rania H. Abd El-Hameed, Shahenda Mahgoub, Hend M. El-Shanbaky, Mosaad S. Mohamed, Sahar A. Ali   +4 more
doaj   +1 more source

Synthesis of New Representatives of Push–Pull Enamines 5-Aryl-3-((dimethylamino)methylene)furan-2(3H)-Ones

Chemistry Proceedings, 2023
The conditions for the synthesis of dimethylaminomethylene derivatives were selected based on the interaction of arylfuran-2(3H)-ones and dimethylformamide dimethylacetal (DMA-DMF), proceeding through the methylene active unit of the furanone ring.
Alexandra S. Tikhomolova, Zhanna V. Mamleeva, Alevtina Yu. Yegorova   +2 more
doaj   +1 more source

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Frontiers in Cellular and Infection Microbiology, 2018
Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar, Derek Gatherer, Chandrajit Lahiri   +2 more
doaj   +1 more source

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Journal of Fungi, 2022
The secondary metabolites of Phaeosphaeria sp. LF5, an endophytic fungus with acetylcholinesterase (AChE) inhibitory activity isolated from Huperzia serrata, were investigated.
Yiwen Xiao, Weizhong Liang, Zhibin Zhang, Ya Wang, Shanshan Zhang, Jiantao Liu, Jun Chang, Changjiu Ji, Du Zhu   +8 more
doaj   +1 more source

Furanone Derivatives from Terrestrial spp

Natural Product Communications, 2012
Chemical investigation of the terrestrial Streptomyces sp. isolates GT2005/020 and ANK148 led to the isolation of two microbial furanone derivatives, 5-hydroxy-4-methylnaphtho[1,2-b]furan-3-one (1) and 4-hydroxy-5-methyl-furan-3-one (2), respectively ...
Muhammad Arfan, Khaled A. Shaaban, Anja Schüffler, Hartmut Laatsch   +3 more
doaj   +1 more source