Results 141 to 150 of about 5,571 (175)

Two furanone glucoside derivatives from Juniperus phœnicea

Phytochemistry, 1996
Abstract The rare compound, psydrin (5-methyl-4-O-(β- d -glucopyranosyl)-3(2H)-furanone) and the new 5-methyl-4-O-(β- d -glucopyranosyl)-3(2-isopropylidenyl)-furanone have been isolated from an acetone extract of the aerial parts of Juniperus phœnicea . Structural elucidation of the new product was achieved mainly by spectroscopic methods.
Gilles Comte, Daovy P. Allais, Albert J. Chulia, Joseph Vercauteren, Christiane Delage   +4 more
openaire   +1 more source

Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa

Applied Microbiology and Biotechnology, 2008
The biofilm formation of Pseudomonas aeruginosa, an opportunistic human pathogen, is developed by cell-to-cell signaling, so-called quorum sensing (QS). To control the biofilm formation, we designed and synthesized new QS inhibitors of P. aeruginosa based on the structure of the previously known QS inhibitor, furanone.
Cheoljin, Kim, Jaeeun, Kim, Hyung-Yeon, Park, Hee-Jin, Park, Joon Hee, Lee, Chan Kyung, Kim, Jeyong, Yoon   +6 more
openaire   +2 more sources

Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors

European Journal of Medicinal Chemistry, 2017
Cdc7 is a serine-threonine kinase and plays a conserved and important role in DNA replication, and it has been recognized as a potential anticancer target. Herein, we report the design, synthesis and structure-activity relationship of novel furanone derivatives as Cdc7 kinase inhibitors.
Takayuki Irie, Tokiko Asami, Ayako Sawa, Yuko Uno, Mitsuharu Hanada, Chika Taniyama, Yoko Funakoshi, Hisao Masai, Masaaki Sawa   +8 more
openaire   +2 more sources

Anti-Cryptococcal activity of a furanone derivative–antibiofilm and opsonophagocytic potential

Journal de Mycologie Médicale, 2020
Cryptococcus neoformans, an encapsulated fungal pathogen is evolving as a major threat to immune-compromised patients and rarely to healthy individuals also. The cell wall bound capsular polysaccharide, melanin pigment and biofilm formation are major virulence factors that are known to contribute to cryptococcal meningitis.
S S, Rathore, T, Raman, C, Lalitha, M, Ramar, A, Munusamy, J, Ramakrishnan   +5 more
openaire   +2 more sources

Baoshanmycin and a New Furanone Derivative from a Soil‐Derived Actinomycete, Amycolatopsis sp. YNNP 00208

Chemistry & Biodiversity, 2022
AbstractActinomycetes have being regarded as a treasure reservoir of various bioactive secondary metabolites and devoted many antibiotics in clinicals. Amycolatopsis sp. YNNP 00208 was isolated from a soil sample collected in Gaoligong Mountain area, Yunnan Province, China.
Meng-An, Qian, Ya-Bin, Yang, Bin-Yuan, Hu, Yuan, Xu, Zi-Hang, Wang, Qin-Yuan, Li, Yu-Hong, Gao, Xiao-Dong, Luo, Li-Xing, Zhao   +8 more
openaire   +2 more sources

Transformations of 3-(methylene)dihydro-2(3H)-furanone derivatives

Collection of Czechoslovak Chemical Communications, 1984
(E) and (Z)-3-(4-toluenesulfonyloxymethylene)dihydro-2(3H)-furanones ((E)-I) and ((Z-I) react with piperidine, pyrrolidine, morpholine, butanethiol, 4-toluenethiol, and 2-naphthalenethiol to give (E)-isomers of the corresponding enamines II-IV and thiomethylene derivatives V-VII in high yields. As has been shown, the reactions proceed with retention of
Ctibor Mazal, Zdeněk Jurka, Jaroslav Jonas   +2 more
openaire   +1 more source

γ -Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178

Phytochemistry, 2017
Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic ...
Patima, Phainuphong, Vatcharin, Rukachaisirikul, Kwanruthai, Tadpetch, Yaowapa, Sukpondma, Saowanit, Saithong, Souwalak, Phongpaichit, Sita, Preedanon, Jariya, Sakayaroj   +7 more
openaire   +2 more sources

Diverse Pharmacological Potential of Various Furanone Derivatives: A Mini-Review

Mini-Reviews in Organic Chemistry, 2020
Abstract:: Furanone is present in many natural compounds. Furanone derivatives are playing important roles in pharmaceutical medicinal and organic chemistry. Various furanone derivatives were exhibited their different pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, antiviral, antioxidant, and other anticipated ...
Asif Husain, Afzal Hussain, Wael A. Mahdi, Mohammad Asif   +3 more
openaire   +1 more source

2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms

BioNanoScience, 2016
© 2016, Springer Science+Business Media New York.The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials.
Elena Trizna, Liliya Latypova, Almira Kurbangalieva, Mikhail I. Bogachev, Airat Kayumov   +4 more
openaire   +3 more sources

Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives

Bioorganic & Medicinal Chemistry, 2010
5-Acetoxymethyl-3-(4-bromophenyl)-2,5-dihydrofuran-2-one previously described as highly antifungally active was found to provide the corresponding 5-methylene derivative via an unusual DMSO-promoted elimination of the ester group at C5 under antifungal assay conditions.
Petr, Senel, Lucie, Tichotová, Ivan, Votruba, Vladimír, Buchta, Marcel, Spulák, Jirí, Kunes, Milan, Nobilis, Ondrej, Krenk, Milan, Pour   +8 more
openaire   +2 more sources