Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-β/ERK Signaling Pathway [PDF]
CellsColorectal cancer (CRC) remains one of the most lethal malignancies worldwide, with 5-fluorouracil (5-Fu) as a mainstay of treatment. However, intrinsic and acquired resistance to 5-Fu significantly limits therapeutic success.
Pratheesh Kumar Poyil +9 more
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Ribonucleotide reductase subunit M2 mediates the mTOR pathway to recruit furin endoprotease and promote maturation of dengue virus [PDF]
iScienceSummary: Dengue virus (DENV) maturation involves calcium-dependent endoprotease furin, which cleaves the precursor membrane (prM) into the M protein in the trans-Golgi network, facilitating the release of infectious virus.
Bouchra Kitab +2 more
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Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development [PDF]
MedCommZona pellucida (ZP) proteins, essential for oocyte development, undergo posttranslational regulation through furin‐mediated cleavage. Nevertheless, our understanding of the functional significance of furin‐mediated cleavage of ZP proteins in female ...
Tiechao Ruan +15 more
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mBio, 2022 Loss of the furin cleavage motif in the SARS-CoV-2 spike protein reduces the virulence and transmission of SARS-CoV-2, suggesting that furin is an attractive antiviral drug target.
Jinliang Wang +12 more
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The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion. [PDF]
PLoS ONE, 2016 The proprotein convertase (PC) furin cleaves precursor proteins, an important step in the activation of many cancer-associated proteins. Substrates of furin and furin-like PCs play a role in proliferation, metastasis and invasion.
Patricia Jaaks +6 more
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Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. [PDF]
PLoS ONE, 2013 Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3).
Kai Kappert +8 more
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The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Translational Neurodegeneration, 2022 Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway.
Yi Zhang +5 more
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Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma. [PDF]
PLoS ONE, 2012 Furin is a member of the pro-protein convertase family. It processes several growth regulatory proteins into their active forms, which are critical to tumor progression, metastasis, and angiogenesis.
Ya-Hui Huang +5 more
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Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults
Frontiers in Endocrinology, 2022 BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese.
Yan He +9 more
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Molecular Oncology, 2023 Furin belongs to the pro‐protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in thyroid cancer remains unclear.
Pratheesh Kumar Poyil +11 more
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