1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
JCI Insight, 2023 Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-
Han Xie +11 more
doaj +3 more sources
The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review
Cancer Reports, 2023 Background Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period.
Hayder M. Al‐kuraishy +6 more
doaj +3 more sources
Cerebral furin deficiency causes hydrocephalus in mice
Genes and DiseasesFurin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice.
Shiqi Xie +7 more
doaj +3 more sources
Geophysical Monograph Series, Page 263-304., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Jessica H. Whiteside +3 more
wiley +1 more source
Frontiers in Immunology, 2021 The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis.
Zsuzsanna Ortutay +6 more
doaj +1 more source
Insights into Omicron’s Low Fusogenicity through Molecular Studies on Spike-Furin Interactions
Bioinformatics and Biology Insights, 2023 The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its subvariants have a unique set of mutations. Two of those mutations (N679 K and P681 H) reside close to the S1 /S2 furin cleavage site (FCS; 685-686).
Spencer Mark Mondol +3 more
doaj +1 more source
FURIN (furin (paired basic amino acid cleaving enzyme)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FURIN (furin (paired basic amino acid cleaving enzyme)), with data on DNA, on the protein encoded, and where the gene is implicated.
Khatib, AM, Sfaxi, F
openaire +2 more sources
FURIN and placental syncytialisation: a cautionary tale [PDF]
Cell Death & Disease, 2021 AbstractFURIN is a pro-protein convertase previously shown to be important for placental syncytialisation (Zhou et al. [1]), a process of cell fusion whereby placental cytotrophoblast cells fuse to form a multinucleated syncytium. This finding has been broadly accepted however, we have evidence suggesting the contrary. Spontaneously syncytialising term
Saije K. Morosin +4 more
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Microbial Cell Factories, 2018 Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang +6 more
doaj +1 more source
A second functional furin site in the SARS-CoV-2 spike protein
Emerging Microbes and Infections, 2022 The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional
Yue Zhang +13 more
doaj +1 more source