1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage [PDF]
JCI Insight, 2023 Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-
Han Xie +11 more
doaj +4 more sources
Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells [PDF]
Frontiers in Immunology, 2021 The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis.
Zsuzsanna Ortutay +6 more
doaj +2 more sources
Cardiology Plus, 2021 Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the underlying mechanisms, but no evidence supports this possibility.
Sheng-Qi Ma +10 more
doaj +2 more sources
Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-β/ERK Signaling Pathway [PDF]
CellsColorectal cancer (CRC) remains one of the most lethal malignancies worldwide, with 5-fluorouracil (5-Fu) as a mainstay of treatment. However, intrinsic and acquired resistance to 5-Fu significantly limits therapeutic success.
Pratheesh Kumar Poyil +9 more
doaj +2 more sources
Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus [PDF]
Cells, 2023 Genome-wide association studies have revealed an association between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. We investigated the mechanism through which rs17514846 modulates FURIN expression.
Wei Yang +3 more
doaj +2 more sources
Ribonucleotide reductase subunit M2 mediates the mTOR pathway to recruit furin endoprotease and promote maturation of dengue virus [PDF]
iScienceSummary: Dengue virus (DENV) maturation involves calcium-dependent endoprotease furin, which cleaves the precursor membrane (prM) into the M protein in the trans-Golgi network, facilitating the release of infectious virus.
Bouchra Kitab +2 more
doaj +2 more sources
Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development [PDF]
MedCommZona pellucida (ZP) proteins, essential for oocyte development, undergo posttranslational regulation through furin‐mediated cleavage. Nevertheless, our understanding of the functional significance of furin‐mediated cleavage of ZP proteins in female ...
Tiechao Ruan +15 more
doaj +2 more sources
The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review
Cancer Reports, 2023 Background Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period.
Hayder M. Al‐kuraishy +6 more
doaj +3 more sources
Cerebral furin deficiency causes hydrocephalus in mice
Genes and DiseasesFurin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice.
Shiqi Xie +7 more
doaj +3 more sources
Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin. [PDF]
J Med ChemLange RW +7 more
europepmc +2 more sources