Results 21 to 30 of about 27,241 (159)

Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury

Biomolecules, 2023
Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh   +5 more
doaj   +1 more source

Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis

Journal of Ovarian Research, 2021
Background Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS.
Yongqian Chen, Jintian Miao, Ge Lou
doaj   +1 more source

Polyarginines Are Potent Furin Inhibitors [PDF]

Journal of Biological Chemistry, 2000
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small nontoxic nanomolar inhibitors have been reported to date.
A, Cameron, J, Appel, R A, Houghten, I, Lindberg   +3 more
openaire   +2 more sources

Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Scientific Reports, 2018
Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin, Eric Hay, Augustin Latourte, Thomas Funck-Brentano, Wafa Bouaziz, Hang-Korng Ea, Abdel-Majid Khatib, Pascal Richette, Martine Cohen-Solal   +8 more
doaj   +1 more source

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

PLoS ONE, 2010
Furin, a specialized endoproteinase, transforms proproteins into biologically active proteins. Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax.
Katarzyna Gawlik, Albert G Remacle, Sergey A Shiryaev, Vladislav S Golubkov, Mingxing Ouyang, Yingxiao Wang, Alex Y Strongin   +6 more
doaj   +1 more source

Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus

Cells, 2023
Genome-wide association studies have revealed an association between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. We investigated the mechanism through which rs17514846 modulates FURIN expression.
Wei Yang, Junjun Cao, David G. McVey, Shu Ye   +3 more
doaj   +1 more source

The association between plasma furin and cardiovascular events after acute myocardial infarction

BMC Cardiovascular Disorders, 2021
Background Furin is the key enzyme involved in the cleavage of pro-BNP and plays a critical role in the cardiovascular system through its involvement in lipid metabolism, blood pressure regulation and the formation of atheromatous plaques.
Zhi-Wei Liu, Qiang Ma, Jie Liu, Jing-Wei Li, Yun-Dai Chen   +4 more
doaj   +1 more source

FURIN promoter methylation predicts the risk of incident hypertension: A prospective analysis of the Gusu cohort

Cardiology Plus, 2021
Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the underlying mechanisms, but no evidence supports this possibility.
Sheng-Qi Ma, Jin-Hua Zhu, Lei Wu, Yan He, Li-Yun Ren, Bin Shen, Jia Yu, Rong-Yan Zhang, Jing Li, Ming-Zhi Zhang, Hao Peng   +10 more
doaj   +1 more source

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics [PDF]

Journal of Medicinal Chemistry, 2009
Furin belongs to the family of proprotein convertases (PCs) and is involved in numerous normal physiological and pathogenic processes, such as viral propagation, bacterial toxin activation, cancer, and metastasis. Furin and related furin-like PCs cleave their substrates at characteristic multibasic consensus sequences, preferentially after an arginine ...
Gero L, Becker, Frank, Sielaff, Manuel E, Than, Iris, Lindberg, Sophie, Routhier, Robert, Day, Yinghui, Lu, Wolfgang, Garten, Torsten, Steinmetzer   +8 more
openaire   +2 more sources

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. [PDF]

PLoS ONE, 2013
There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues
Sergey A Shiryaev, Andrei V Chernov, Vladislav S Golubkov, Elliot R Thomsen, Eugene Chudin, Mark S Chee, Igor A Kozlov, Alex Y Strongin, Piotr Cieplak   +8 more
doaj   +1 more source