Results 21 to 30 of about 1,635 (78)

Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer

International Journal of Cancer, EarlyView.
What's New? In this prospective study, the authors evaluated the discrimination capacity of 92 cancer‐related proteins as potential early detection biomarkers for endometrial cancer using blood samples from two large‐scale European population cohorts (EPIC and Janus).
Victoria Cooley, Renée Turzanski Fortner, Trasias Mukama, Sabine Naudin, Valeria Pala, Laure Dossus, Inger T. Gram, Karina Standahl Olsen, Maria‐Jose Sánchez, Pernilla Israelsson, Naomi Allen, Hilde Langseth, Rudolf Kaaks   +12 more
wiley   +1 more source

A novel genotyping system based on site polymorphism on spike gene reveals the evolutionary pathway of porcine epidemic diarrhea virus

iMetaOmics, EarlyView.
This study focuses on porcine epidemic diarrhea virus (PEDV), a highly virulent and rapidly evolving coronavirus threatening global swine production. We established a novel genotype system of PEDV targeting site‐specific polymorphisms in the spike (S) protein.
Mingkai Lei, Huimin Li, Xiaoyu Chen, Xiaozhen Li, Xuexiang Yu, Shengnan Ruan, Hao Wu, Ahmed H. Ghonaim, Ziyang Yan, Wentao Li, Qigai He   +10 more
wiley   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Zebrafish in neurodevelopmental disorders studies: Genetic models and pathological involvement of microglia

Developmental Medicine &Child Neurology, EarlyView.
The relevance of the pathogenic (de novo or inherited) mutations found in patients with neurodevelopmental disorders can be investigated using zebrafish as an animal model, by functional screening of the target genes and phenotypic assessments during both early development and adulthood. Abstract Neurodevelopmental disorders (NDDs) are a group of brain
Fatemeh Hassani Nia, Valerie Wittamer
wiley   +1 more source

Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters [PDF]

, 1999
Ajoy Basak, Sam F. Cooper, Andrée G. Roberge, Upen K. BANIK, Michel Chrètien, Nabil G. Seidah   +5 more
openalex   +2 more sources

Human Impacts on Great Lakes Walleye Sander vitreus Structure, Diversity and Local Adaptation

Molecular Ecology, EarlyView.
ABSTRACT Artificial propagation and wild release may influence the genetic integrity of wild populations. This practice has been prevalent in fisheries for centuries and is often termed ‘stocking’. In the Laurentian Great Lakes (Great Lakes here‐on), walleye populations faced declines from the 1950s to the 1970s, prompting extensive stocking efforts ...
Peter T. Euclide, Heiner Kuhl, Chris C. Wilson, Kim T. Scribner, Loren M. Miller, Wendylee Stott, Wesley A. Larson   +6 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, EarlyView.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, EarlyView.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source

Preascitic Sodium Retention in Cirrhosis: A Role for Disregulated Proteolysis by Proprotein Convertases?

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè, Manuela Aragno, Florence Wong   +2 more
wiley   +1 more source