mBio, 2022 Loss of the furin cleavage motif in the SARS-CoV-2 spike protein reduces the virulence and transmission of SARS-CoV-2, suggesting that furin is an attractive antiviral drug target.
Jinliang Wang +12 more
doaj +1 more source
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion. [PDF]
PLoS ONE, 2016 The proprotein convertase (PC) furin cleaves precursor proteins, an important step in the activation of many cancer-associated proteins. Substrates of furin and furin-like PCs play a role in proliferation, metastasis and invasion.
Patricia Jaaks +6 more
doaj +1 more source
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. [PDF]
PLoS ONE, 2013 Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3).
Kai Kappert +8 more
doaj +1 more source
The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Translational Neurodegeneration, 2022 Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway.
Yi Zhang +5 more
doaj +1 more source
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma. [PDF]
PLoS ONE, 2012 Furin is a member of the pro-protein convertase family. It processes several growth regulatory proteins into their active forms, which are critical to tumor progression, metastasis, and angiogenesis.
Ya-Hui Huang +5 more
doaj +1 more source
Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults
Frontiers in Endocrinology, 2022 BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese.
Yan He +9 more
doaj +1 more source
Molecular Oncology, 2023 Furin belongs to the pro‐protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in thyroid cancer remains unclear.
Pratheesh Kumar Poyil +11 more
doaj +1 more source
Geophysical Monograph Series, Page 263-304., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Jessica H. Whiteside +3 more
wiley +1 more source
Insights into Omicron’s Low Fusogenicity through Molecular Studies on Spike-Furin Interactions
Bioinformatics and Biology Insights, 2023 The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its subvariants have a unique set of mutations. Two of those mutations (N679 K and P681 H) reside close to the S1 /S2 furin cleavage site (FCS; 685-686).
Spencer Mark Mondol +3 more
doaj +1 more source
Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus. [PDF]
Microbiol SpectrYeh T-Y +9 more
europepmc +3 more sources