Results 31 to 40 of about 28,655 (201)
FURIN (furin (paired basic amino acid cleaving enzyme)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on FURIN (furin (paired basic amino acid cleaving enzyme)), with data on DNA, on the protein encoded, and where the gene is implicated.
Khatib, AM, Sfaxi, F
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FURIN and placental syncytialisation: a cautionary tale [PDF]
Cell Death & Disease, 2021 AbstractFURIN is a pro-protein convertase previously shown to be important for placental syncytialisation (Zhou et al. [1]), a process of cell fusion whereby placental cytotrophoblast cells fuse to form a multinucleated syncytium. This finding has been broadly accepted however, we have evidence suggesting the contrary. Spontaneously syncytialising term
Saije K. Morosin +4 more
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Processing of proendothelin‐1 by human furin convertase [PDF]
FEBS Letters, 1995 Endothelin‐1 (ET‐1) is the most potent vasoactive peptide known to date. The peptide is initially synthesized as an inactive precursor (proET‐1) which undergoes proteolysis at specific pairs of basic amino acids to yield bigET‐1. Production of ET‐1 then proceeds by cleavage of bigET‐1 by the endothelin converting enzyme (ECE). Here, we demonstrate that
Jean‐Bernard Denault +6 more
openalex +3 more sources
Microbial Cell Factories, 2018 Background Proprotein convertase furin is responsible for the processing of a wide variety of precursors consisted of signal peptide, propeptide and mature peptide in mammal.
Yide Huang +6 more
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Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury
Biomolecules, 2023 Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato +5 more
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A second functional furin site in the SARS-CoV-2 spike protein
Emerging Microbes and Infections, 2022 The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional
Yue Zhang +13 more
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Journal of Ovarian Research, 2021 Background Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS.
Yongqian Chen, Jintian Miao, Ge Lou
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Polyarginines Are Potent Furin Inhibitors [PDF]
Journal of Biological Chemistry, 2000 The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small nontoxic nanomolar inhibitors have been reported to date.
A, Cameron +3 more
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Scientific Reports, 2018 Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin +8 more
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PLoS ONE, 2010 Furin, a specialized endoproteinase, transforms proproteins into biologically active proteins. Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax.
Katarzyna Gawlik +6 more
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