Furin - Open Access .click

Results 31 to 40 of about 1,635 (78)

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system. [PDF]

, 1994
Herbert Bosshart +8 more
openalex +1 more source

Modeling Stromal Cells Inside the Tumor Microenvironment of Ovarian Cancer: In Vitro Generation of Cancer‐Associated Fibroblast‐Like Cells and Their Impact in a 3D Model

MedComm, Volume 6, Issue 5, May 2025.
Conditioned medium from ovarian cancer cell lines influences fibroblast differentiation into distinct CAF subpopulations (iCAF, myCAF). A 3D model mimicking the tumor microenvironment was developed to study CAF roles in tumor spheroid growth and invasion.
Jacopo Romoli +11 more
wiley +1 more source

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse

FASEB BioAdvances, Volume 7, Issue 5, May 2025.
Furin interacted with PTEN‐L and activated PINK1/Parkin‐mediated mitophagy in HSCs. Furin inhibited HSC activation and alleviated liver fibrosis by regulating the PTEN‐L/PINK1/Parkin axis. Abstract Hepatic Stellate cells (HSCs) play an important role during liver fibrosis progression; more and more evidence indicates that mitophagy greatly regulates ...
Yan‐Wei Song, Yu‐Hua Zhu, Ming‐Ze Ma +2 more
wiley +1 more source

An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor [PDF]