Results 31 to 40 of about 27,241 (159)
Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network [PDF]
Journal of Cell Science, 2008 Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling and trafficking of membrane proteins.
Jinbo, Han +3 more
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A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +1 more source
Emerging Microbes and Infections, 2022 Swine acute diarrhea syndrome coronavirus (SADS-CoV) was reported in China in 2017 and is a causative agent of porcine enteric disease. Recent studies indicate that cells from various hosts are susceptible to SADS-CoV, suggesting the zoonotic potential ...
Jinman Kim, Jaewon Yoon, Jung-Eun Park
doaj +1 more source
A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness
Neoplasia: An International Journal for Oncology Research, 2008 Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway.
Julia M. Coppola +3 more
doaj +1 more source
Enhanced expression of a furin-cleavable proinsulin [PDF]
Journal of Molecular Endocrinology, 2003 Cell engineering or gene therapy may represent an alternative to current methods of treating diabetes mellitus. Cells could be engineered to secrete insulin ex vivo for transplantation or the insulin gene could be administered directly by injection into muscle. A problem has been that non-neuroendocrine cells lack the endoproteases (PC3/1 and PC2) that
C W, Hay, K, Docherty
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Haematologica, 2010 Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli +7 more
doaj +1 more source
Transgenic overexpression of furin increases epileptic susceptibility [PDF]
Cell Death & Disease, 2018 AbstractThe proprotein convertase Furin plays crucial roles in the pathology of many diseases. However, the specific role of furin in epilepsy remains unclear. In our study, furin protein was increased in the temporal neocortex of epileptic patients and in the hippocampus and cortex of epileptic mice.
Yi Yang +14 more
openaire +2 more sources
Advanced ScienceFurin primarily localizes to the trans‐Golgi network (TGN), where it cleaves and activates a broad range of immature proproteins that play critical roles in cellular homeostasis, disease progression, and infection.
Wenqiang Su +8 more
doaj +1 more source
Furin cleavage sites naturally occur in coronaviruses
Stem Cell Research, 2021 The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree ...
Wu, Yiran, Zhao, Suwen
openaire +3 more sources