Results 41 to 50 of about 28,655 (201)
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. [PDF]
PLoS ONE, 2013 There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues
Sergey A Shiryaev +8 more
doaj +1 more source
Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics [PDF]
Journal of Medicinal Chemistry, 2009 Furin belongs to the family of proprotein convertases (PCs) and is involved in numerous normal physiological and pathogenic processes, such as viral propagation, bacterial toxin activation, cancer, and metastasis. Furin and related furin-like PCs cleave their substrates at characteristic multibasic consensus sequences, preferentially after an arginine ...
Gero L, Becker +8 more
openaire +2 more sources
The association between plasma furin and cardiovascular events after acute myocardial infarction
BMC Cardiovascular Disorders, 2021 Background Furin is the key enzyme involved in the cleavage of pro-BNP and plays a critical role in the cardiovascular system through its involvement in lipid metabolism, blood pressure regulation and the formation of atheromatous plaques.
Zhi-Wei Liu +4 more
doaj +1 more source
Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network [PDF]
Journal of Cell Science, 2008 Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling and trafficking of membrane proteins.
Jinbo, Han +3 more
openaire +2 more sources
Emerging Microbes and Infections, 2022 Swine acute diarrhea syndrome coronavirus (SADS-CoV) was reported in China in 2017 and is a causative agent of porcine enteric disease. Recent studies indicate that cells from various hosts are susceptible to SADS-CoV, suggesting the zoonotic potential ...
Jinman Kim, Jaewon Yoon, Jung-Eun Park
doaj +1 more source
A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness
Neoplasia: An International Journal for Oncology Research, 2008 Furin, a member the proprotein convertase (PC) family, processes inactive precursor proteins to functional proteins within the Golgi/trans-Golgi network secretory pathway.
Julia M. Coppola +3 more
doaj +1 more source
A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +1 more source
Enhanced expression of a furin-cleavable proinsulin [PDF]
Journal of Molecular Endocrinology, 2003 Cell engineering or gene therapy may represent an alternative to current methods of treating diabetes mellitus. Cells could be engineered to secrete insulin ex vivo for transplantation or the insulin gene could be administered directly by injection into muscle. A problem has been that non-neuroendocrine cells lack the endoproteases (PC3/1 and PC2) that
C W, Hay, K, Docherty
openaire +2 more sources
Haematologica, 2010 Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli +7 more
doaj +1 more source