Results 41 to 50 of about 27,241 (159)
iNew Medicine, EarlyView.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.
PLoS Pathogens, 2021 Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion.
Guido Papa +11 more
doaj +1 more source
A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors
Small, EarlyView.The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang +4 more
wiley +1 more source
The role of furin in papillomavirus infection [PDF]
Future Microbiology, 2009 Papillomaviruses represent a medically important virus family. Infection with a high-risk human papillomavirus type is a prerequisite for cervical carcinoma development. Infection by low-risk types may result in the generation of benign skin warts. It was recently found that infectious entry of these viruses is dependent upon a specific proteolytic ...
Patricia M, Day, John T, Schiller
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Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
ACS Medicinal Chemistry Letters, 2023 Furin is a human serine protease responsible for activating numerous physiologically relevant cell substrates and is also involved in the development of various pathological conditions, including inflammatory diseases, cancers, and viral and bacterial infections.
Agata Gitlin-Domagalska +7 more
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Integrative Zoology, EarlyView.We found that teleosts employed two different strategies to ensure sufficient ZP (zona pellucida) synthesis: expansion of ZPB1(a) and ZPC1(a) in basal species or liver expression of ZPB1a and ZPC1aa in advanced species. The N‐terminus of expanded ZPB1(a) or ZPC1(a) and liver‐expressed ZPB1a contains repeated units or low‐complexity regions to form ...
Tian Gao +8 more
wiley +1 more source
Secretion of Human Furin into Mouse Milk [PDF]
Journal of Biological Chemistry, 1997 We have previously described the expression of the human proprotein convertase furin or paired basic amino acid-cleaving enzyme, in mice transgenic for paired basic amino acid-cleaving enzyme and human Protein C (HPC). Here we show 100-fold or higher expression of furin in the mammary gland, compared with endogenous furin.
R K, Paleyanda +3 more
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The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Pan-Cancer Analysis of FURIN as a Potential Prognostic and Immunological Biomarker
Frontiers in Molecular Biosciences, 2021 BackgroundFurin is a calcium-dependent protease that processes various precursor proteins through diverse secretory pathways. The deregulation of FURIN correlated with the prognosis of patients in numerous diseases.
Bolun Zhou, Shugeng Gao
doaj +1 more source
The proprotein convertase furin in tumour progression [PDF]
International Journal of Cancer, 2017 Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Jaaks, Patricia, Bernasconi, Michele
openaire +3 more sources