Results 71 to 80 of about 27,241 (159)

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, Volume 3, Issue 1, March 2026.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

Frontiers in Microbiology, 2017
Human cytomegalovirus is a ubiquitous infectious agent that affects mainly immunosuppressed, fetuses, and newborns. The virus has several polymorphic regions, in particular in the envelope glycoproteins.
Lucas M. Stangherlin, Felipe N. de Paula, Felipe N. de Paula, Marcelo Y. Icimoto, Leonardo G. P. Ruiz, Maurício L. Nogueira, Antônio S. K. Braz, Luiz Juliano, Maria C. C. da Silva   +8 more
doaj   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host.

PLoS ONE, 2015
Bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including Ebola virus, SARS-like coronavirus and the henipaviruses.
Farah El Najjar, Levi Lampe, Michelle L Baker, Lin-Fa Wang, Rebecca Ellis Dutch   +4 more
doaj   +1 more source

Structural Basis of MERS‐CoV Receptor Interactions and Antibody Neutralisations

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Increasing outbreaks of coronaviruses underscore the importance of antivirals and vaccines that can combat a wide range of coronaviruses. Neutralising antibodies (nAbs), along with vaccines and small‐molecule drugs, are among the most promising treatments and prevention options against coronaviruses.
Edem Gavor, Yeu Khai Choong, Sunil Singh, Hariharan Sivaraman, Er Shi Yin, J. Sivaraman   +5 more
wiley   +1 more source

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection

Viruses, 2015
Infections by high-risk human papillomaviruses (HPV) are the causative agents for the development of cervical cancer. As with other non-enveloped viruses, HPVs are taken up by the cell through endocytosis following primary attachment to the host cell ...
Linda Cruz, Jennifer Biryukov, Michael J. Conway, Craig Meyers   +3 more
doaj   +1 more source

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Neoplasia: An International Journal for Oncology Research, 2013
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto   +7 more
doaj   +1 more source

Processing of proendothelin‐1 by human furin convertase

FEBS Letters, 1995
Endothelin‐1 (ET‐1) is the most potent vasoactive peptide known to date. The peptide is initially synthesized as an inactive precursor (proET‐1) which undergoes proteolysis at specific pairs of basic amino acids to yield bigET‐1. Production of ET‐1 then proceeds by cleavage of bigET‐1 by the endothelin converting enzyme (ECE). Here, we demonstrate that
Denault, Jean-Bernard, Claing, Audrey, D'Orléans-Juste, Pedro, Sawamura, Tatsuya, Kido, Tsuneo, Masaki, Tomoh, Leduc, Richard   +6 more
openaire   +2 more sources