Results 71 to 80 of about 28,655 (201)
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Furin cleavage of the HIV‐1 Tat protein [PDF]
FEBS Letters, 2004 Extracellular human immunodeficiency virus‐1 (HIV‐1) Tat protein and Tat‐derived peptides are biologically active but mechanisms of Tat processing are not known. Within the highly conserved basic region of HIV‐1 Tat protein (amino acids, a.a. 48–56), we identified two putative furin cleavage sites and showed that Tat protein was cleaved in vitro at the
Tikhonov, Ilia +4 more
openaire +2 more sources
Plant Biotechnology Journal, EarlyView.Engineering of marker‐free lettuce chloroplast genome to express CTB‐Exenatide and CTB‐Lixisenatide for oral delivery. Upper panel: Chemically synthesised exenatide or lixisenatide require expensive production, purification, refrigeration and invasive delivery methods.
Rahul Singh, Henry Daniell
wiley +1 more source
Biochemistry Research International, 2011 Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood.
Maria Pavlaki +5 more
doaj +1 more source
Veterinary Clinical Pathology, EarlyView.ABSTRACT Background Point‐of‐care testing (POC) is widely utilized for rapid results for many different analytes. A new feline‐specific N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) quantitative assay (Vcheck V200, Bionote Inc) is currently available but has not undergone independent validation.
Emily A. Javery +6 more
wiley +1 more source
A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. [PDF]
PLoS ONE, 2009 Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis.
Ajoy Basak +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth +16 more
wiley +1 more source
The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2014 Animals sample their environment through sensory neurons with often elaborately branched endings named dendritic arbors. In a genetic screen for genes involved in the development of the highly arborized somatosensory PVD neuron in C.
Yehuda Salzberg +2 more
doaj +1 more source
Integrating evidence from protein domains to identify cancer driver mutations
Protein Science, Volume 35, Issue 2, February 2026.Abstract Cancer can develop through the accumulation of somatic mutations that drive uncontrolled cell proliferation. A central objective in cancer research is to identify mutations that provide a selective growth advantage to tumor cells, so‐called driver mutations.
Daria Ostroverkhova +3 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Genome‐wide association studies have shown an association between the single‐nucleotide polymorphism rs17514846 on chromosome 15q26.1 and coronary artery disease susceptibility.
Xu Yang +14 more
doaj +1 more source