Results 201 to 210 of about 7,541,115 (355)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Preparation, expression, and anti-cancer effects of the novel fusion protein rONC-T7-pHLIP. [PDF]

Appl Microbiol Biotechnol
Yang G, Wang S, Wang Y, Zheng H, Du M, Wang Z, Chen Z, Chang C, Yu G.   +8 more
europepmc   +1 more source

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

Antimicrobial Agents and Chemotherapy, 2016
Mizuki Yamamoto, S. Matsuyama, Xiao Li, M. Takeda, Y. Kawaguchi, J. Inoue, Z. Matsuda   +6 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Modulation of specific interactions within a viral fusion protein predicted from machine learning blocks membrane fusion. [PDF]

Nanoscale
Odstrcil RE, Makio AO, Hull MA, Dutta P, Nicola AV, Liu J.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell-induced pregnancy loss model. [PDF]

Front Pharmacol
Li G, Wang T, Tan D, Jin Y, Zhou X, Ai H, Zheng X, Ren X, Hu S, Lei C, Fu W.   +10 more
europepmc   +1 more source

NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls

Modern Pathology, 2019
James P. Solomon, I. Linkov, Andréa Rosado, Kerry A Mullaney, Ezra Y. Rosen, D. Frosina, A. Jungbluth, A. Zehir, R. Benayed, A. Drilon, D. Hyman, M. Ladanyi, A. Sireci, J. Hechtman   +13 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Preparation of ESAT6-Fc Fusion Protein and Its Therapeutic Efficacy and Immune Mechanisms in Allergic Asthma Mice via Intranasal Immunization. [PDF]

Molecules
Wang J, Hai M, Yang Y, Wang T, Zhang W, Ma R, Sun M, Qin Y, Yang Y, Dong Z, Yang M, Wan Q.   +11 more
europepmc   +1 more source