Results 41 to 50 of about 1,121,449 (385)
Frontiers in Immunology, 2019 Background: Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion ...
Xunyan Ye +11 more
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OncoImmunology, 2023 Mesothelin (MSLN) is an attractive immuno-oncology target, but the development of MSLN-targeting therapies has been impeded by tumor shedding of soluble MSLN (sMSLN), on-target off-tumor activity, and an immunosuppressive tumor microenvironment.
Daniel Snell +22 more
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Mitochondrial Fusion Proteins and Human Diseases [PDF]
Neurology Research International, 2013 Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important ...
M. Ranieri +7 more
openaire +5 more sources
Unimolecular FRET Sensors: Simple Linker Designs and Properties [PDF]
Nano Communication Networks Volume 7, 2016, Pages 27-45, 2018 Protein activation and deactivation is central to a variety of biological mechanisms, including cellular signaling and transport. Unimolecular fluorescent resonance energy transfer (FRET) probes are a class of fusion protein sensors that allow biologists to visualize using an optical microscope whether specific proteins are activated due to the ...
arxiv +1 more source
Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor [PDF]
, 1996 The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system.
Alan J. Rosenstein +51 more
core +1 more source
Biomolecules, 2020 Caspase-2 is the most specific protease of all caspases and therefore highly suitable as tag removal enzyme creating an authentic N-terminus of overexpressed tagged proteins of interest.
Monika Cserjan-Puschmann +14 more
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The Tribble with APL: a new road to therapy [PDF]
, 2017 The t(15;17) translocation generates a PML-RARα fusion protein causative for acute promyelocytic leukemia (APL). Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disease progression and therapy resistance ...
Carmody, Ruaidhri, Keeshan, Karen
core +1 more source
Methods and Protocols, 2020 The limited amount of fusion protein transported into cytosol milieu has made it challenging to obtain a sufficient amount for further applications. To avoid the laborious and expensive task, T7 promoter-driving pET-30a(+) coding for chimeric gene of ...
Ammar Tarar +2 more
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Timescales of Cell Membrane Fusion Mediated by SARS-CoV2 Spike Protein and its Receptor ACE2 [PDF]
arXiv, 2023 In this manuscript we describe the investigation of the SARS-CoV2 membrane fusion timescale by means of small-angle neutron scattering (SANS) using hydrogen/deuterium contrast variation. After the successful production of virus-like vesicles and human-host-cell-like vesicles we were able to follow the fusion of the respective vesicles in real-time ...
arxiv
Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-mimetic, Elastin-like Fusion Protein [PDF]
Biomacromolecules, 2016, 2016 Native extracellular matrices (ECMs), such as those of the human brain and other neural tissues, exhibit networks of molecular interactions between specific matrix proteins and other tissue components. Guided by these naturally self-assembling supramolecular systems, we have designed a matrix-derived protein chimera that contains a laminin globular ...
arxiv +1 more source