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Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]

open access: yes, 2008
Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
A Bracher   +42 more
core   +42 more sources

Fusion-protein-assisted protein crystallization [PDF]

open access: yesActa Crystallographica Section F Structural Biology Communications, 2015
Fusion proteins can be used directly in protein crystallization to assist crystallization in at least two different ways. In one approach, the ‘heterologous fusion-protein approach’, the fusion partner can provide additional surface area to promote ...
Kobe, Bostjan   +2 more
core   +6 more sources

Bioluminescence Resonance Energy Transfer (BRET) Allows Monitoring the Barnase-Barstar Complex In Vivo

open access: yesBiophysica, 2022
Bioluminescence resonance energy transfer (BRET) seems to be a promising biophysical technique to study protein–protein interactions within living cells due to a very specific reaction of bioluminescence that essentially decreases the background of other
Victor Marchenkov   +4 more
doaj   +1 more source

Double Proteolysis for N- and O-glycan Analysis of Fc-fusion Protein Etanercept

open access: yesРазработка и регистрация лекарственных средств, 2023
Introduction. Highly glycosylated proteins are the most abundant class of modern biopharmaceuticals. A majority of such therapeuticals produced by Russian biopharmaceutical companies is biosimilars.
V. G. Varzieva   +4 more
doaj   +1 more source

ViralFP: A Web Application of Viral Fusion Proteins

open access: yesFrontiers in Medical Technology, 2021
Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the ...
Pedro Moreira   +5 more
doaj   +1 more source

Long acting growth hormone (LAGH), an update

open access: yesFrontiers in Pediatrics, 2023
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo   +2 more
doaj   +1 more source

Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects

open access: yesPharmaceutics, 2023
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity.
Vladislav S. Rybchenko   +4 more
doaj   +1 more source

The FUSION protein crystallization screen

open access: yesJournal of Applied Crystallography, 2022
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening crystallization conditions often consumes large amounts of sample and time.
Gorrec, Fabrice, Bellini, Dom
openaire   +3 more sources

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

open access: yeseLife, 2021
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogenic ...
Nicole Merritt   +11 more
doaj   +1 more source

Elucidation of the Cellular Interactome of African Swine Fever Virus Fusion Proteins and Identification of Potential Therapeutic Targets

open access: yesViruses, 2023
African swine fever virus (ASFV) encodes more than 150 proteins, most of them of unknown function. We used a high-throughput proteomic analysis to elucidate the interactome of four ASFV proteins, which potentially mediate a critical step of the infection
Isabel García-Dorival   +6 more
doaj   +1 more source

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