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Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]
, 2008 Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
A Bracher +42 more
core +42 more sources
Fusion-protein-assisted protein crystallization [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2015 Fusion proteins can be used directly in protein crystallization to assist crystallization in at least two different ways. In one approach, the ‘heterologous fusion-protein approach’, the fusion partner can provide additional surface area to promote ...
Kobe, Bostjan +2 more
core +6 more sources
Biophysica, 2022 Bioluminescence resonance energy transfer (BRET) seems to be a promising biophysical technique to study protein–protein interactions within living cells due to a very specific reaction of bioluminescence that essentially decreases the background of other
Victor Marchenkov +4 more
doaj +1 more source
Double Proteolysis for N- and O-glycan Analysis of Fc-fusion Protein Etanercept
Разработка и регистрация лекарственных средств, 2023 Introduction. Highly glycosylated proteins are the most abundant class of modern biopharmaceuticals. A majority of such therapeuticals produced by Russian biopharmaceutical companies is biosimilars.
V. G. Varzieva +4 more
doaj +1 more source
ViralFP: A Web Application of Viral Fusion Proteins
Frontiers in Medical Technology, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the ...
Pedro Moreira +5 more
doaj +1 more source
Long acting growth hormone (LAGH), an update
Frontiers in Pediatrics, 2023 In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo +2 more
doaj +1 more source
Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
Pharmaceutics, 2023 Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity.
Vladislav S. Rybchenko +4 more
doaj +1 more source
The FUSION protein crystallization screen
Journal of Applied Crystallography, 2022 The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening crystallization conditions often consumes large amounts of sample and time.
Gorrec, Fabrice, Bellini, Dom
openaire +3 more sources
eLife, 2021 Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogenic ...
Nicole Merritt +11 more
doaj +1 more source
Viruses, 2023 African swine fever virus (ASFV) encodes more than 150 proteins, most of them of unknown function. We used a high-throughput proteomic analysis to elucidate the interactome of four ASFV proteins, which potentially mediate a critical step of the infection
Isabel García-Dorival +6 more
doaj +1 more source