Results 91 to 100 of about 9,645 (157)
Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript
Pakistan Journal of Medicine and DentistryChronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum +3 more
doaj
Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene [PDF]
, 2006 Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis.
Acunzo, Mario +7 more
core +2 more sources
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32) [PDF]
, 2005 The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL).
Cools, J. (J.) +10 more
core +1 more source
Iatreia, 2014 Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto +10 more
doaj
Stat5 as a diagnostic marker for leukemia
, 2008 The Jak-Stat-Socs pathway is an important component of cytokine receptor signaling. Not surprisingly, perturbation of this pathway is implicated in diseases of hematopoietic and immune origin, including leukemia, lymphoma and immune deficiencies.
Lewis, Rowena S., Ward, Alister
core +1 more source
Genetically engineered mouse models of human B-cell precursor leukemias [PDF]
, 2016 This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License.B-cell precursor acute lymphoblastic leukemias (pB-ALLs) are the most frequent type of malignancies of the childhood, and also affect ...
Borkhardt, Arndt +3 more
core +1 more source
Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity [PDF]
, 2014 Previous studies have demonstrated that p210 BCR/ABL1 interacts directly with the xeroderma pigmentosum group B (XPB) protein, and that XPB is phosphorylated on tyrosine in cells that express p210 BCR/ABL1.
Adams III, H C +14 more
core +1 more source
Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]
ACS Medicinal Chemistry Letters, 2020 openaire +3 more sources
Dissecting BCR-ABL Variant Signaling Pathways Using Novel Interactome Identification Strategies [PDF]
, 2019 Cell signaling is an essential function of cells and tissues. Understanding cell signaling necessitates technologies that can identify protein-protein interactions as well as post translational modifications to proteins within protein complexes.
Cutler, Jevon A
core
Di-san junyi daxue xuebao, 2021 Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL ...
CHEN Siyu +6 more
openaire +1 more source