Results 91 to 100 of about 20,944 (184)

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. [PDF]

, 2014
To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis.
Alessandro Fantin, Anastasia Lampropoulou, Anissa Chikh, Anselmi, Ballmer-Hofer, Baruzzi, Birukova, Buchdunger, Campochiaro, Carmeliet, Casanovas, Chen, Chen, Chislock, Cho, Choi, Christiana Ruhrberg, Clark, Claudio Raimondi, Colicelli, Connor, Cui, Cujec, Dejana, Druker, Fantin, Fantin, Fantin, Fantin, Foxton, Fukasawa, Gerhardt, Gerhardt, Herzog, Kawamura, Kawasaki, Kim, Kitsukawa, Koch, Lanahan, Lanahan, Laura Denti, Lewis, Lewis, Mamluk, Murga, Nishijima, Pan, Pan, Parsons, Pasapera, Phng, Raimondi, Ren, Robinson, Roig, Rosenfeld, Ruhrberg, Ruhrberg, Saint-Geniez, Salikhova, Shimizu, Shojaei, Smith, Soker, Sottile, Stenzel, Tvorogov, Uemura, Valdembri, Wang, Welti, Yaqoob, Zaidel-Bar, Zhuang   +74 more
core   +4 more sources

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. [PDF]

, 1995
To determine the functional importance of Ras in transformation by Abl oncogenes, we used a genetic approach to measure the effect of impaired Ras activity on the ability of Bcr-Abl or v-Abl to transform cells.
McLaughlin, J, Sawyers, CL, Witte, ON
core  

C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia [PDF]

, 2015
Accumulating evidences indicate that different long non-coding RNAs (lncRNAs) might play a relevant role in tumorigenesis, with their expression and function already associated to cancer development and progression.
Bozzoni, Irene, Fatica, Alessandro, Fazi, Francesco, Hughes, JAMES M., Legnini, Ivano, Marchioni, M, Masciarelli, Silvia, Morlando, Mariangela, Salvatori, Beatrice   +8 more
core   +2 more sources

Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia [PDF]

, 2017
Approximately 15% of pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by gene expression similar to that of BCR-ABL1-positive disease and unfavorable prognosis. This BCR-ABL1-like subtype shows a high frequency of B-cell
Beaudoin, E.L., Beverloo, H.B. (Berna), Boer, J.M. (Judith), Boer, M.L. (Monique) den, Boeree, A. (Aurélie), de Groot-Kruseman, H.A. (Hester A.), Escherich, G. (Gabriele), Kuiper, R. (Ruud), Marchante, J.R.M. (João R.), Pieters, R. (Rob), Schoot, C.E. (Ellen) van der, Steeghs, E.M.P. (Elisabeth M.P.), Velden, V.H.J. (Vincent) van der   +12 more
core   +4 more sources

Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity [PDF]

, 2014
Previous studies have demonstrated that p210 BCR/ABL1 interacts directly with the xeroderma pigmentosum group B (XPB) protein, and that XPB is phosphorylated on tyrosine in cells that express p210 BCR/ABL1.
Adams III, H C, Chen, R, Ciccarelli, B T, Fitzpatrick, E R, Hu, T, Lagunoff, D, Li, D, Megjugorac, N J, Pannucci, N L, Rodriguez, P L, Sahay, S, Tala, I, Thomas, E K, Whitehead, I P, Williams, D A   +14 more
core   +1 more source

MOLECULAR CHARACTERIZATION OF DIFFERENT GENE FUSIONS ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN FROM THE BRAZILIAN AMAZON

Hematology, Transfusion and Cell Therapy
Objective: Acute Lymphoblastic Leukemia (ALL) is classified according to its genetic abnormalities, which are associated with the clinical and biological characteristics of the disease.
MB Oliveira, ATM Tavares, LB Rotella, MS Aquino, KVM Queiroz, EJC Botelho, FMCP Pessoa, AV Wanderley, CA Moreira-Nunes, AS Khayat   +9 more
doaj   +1 more source

Advances in targeted degradation of endogenous proteins [PDF]

, 2019
Protein silencing is often employed as a means to aid investigations in protein function and is increasingly desired as a therapeutic approach. Several types of protein silencing methodologies have been developed, including targeting the encoding genes ...
Fulcher, Luke, Roth, Sascha, Sapkota, Gopal   +2 more
core   +2 more sources

Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

Phosphorylation activity and specificity of the oncogenic tyrosine kinase fusion protein BCR/ABL

, 2021
Tyrosinphosphorylierung (pTyr) ist ein zentraler Bestandteil vieler zellulärer Signalpfade und ihre Deregulation führt zu Krebserkrankungen wie Leukämie. Kinase-Substrat-Annotation ist unerlässlich um das Krankheitsbild zu verstehen. Diese wird jedoch von Kinasenredundanz, Spezifitätsüberlappung und Aktivitätsdifferenzen erschwert.Das ...
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