Results 121 to 130 of about 9,645 (157)

Flow Cytometry Detection of BCR-ABL Fusion Proteins in Leukemia Patients- An Indian Experience.

Blood, 2009
Abstract Abstract 4710 Background The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor risk subgroup of precursor B cell Acute Lymphoblastic Leukemia(ALL),which represents 25 to 30% of adult ALL and
Sanjay Sarkar, Jayasri Basak, U.K. Roy, P. Gupta, Haemato Ashis Mukhopadhyay, R. Pandey, Soma Mukhopadhyay   +6 more
openaire   +2 more sources

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

Leukemia, 2017
Two major types of leukemogenic BCR-ABL fusion proteins are p190BCR-ABLand p210BCR-ABL. Although the two fusion proteins are closely related, they can lead to different clinical outcomes. A thorough understanding of the signaling programs employed by these two fusion proteins is necessary to explain these clinical differences.
Mohammad Heydarian, Akhilesh Pandey, Chris J. Mitchell, Santosh Renuse, Min-Sik Kim, Min-Sik Kim, X. Wong, Karen L. Reddy, Sreelakshmi K. Sreenivasamurthy, Xinyan Wu, Arun H. Patil, Arun H. Patil, Tai-Chung Huang, Tai-Chung Huang, Jevon Cutler, Raiha Tahir, Raja Sekhar Nirujogi   +16 more
openaire   +3 more sources

TAT-CC fusion protein depresses the oncogenicity of BCR-ABL in vitro and in vivo through interrupting its oligomerization

Amino Acids, 2012
Chronic myeloid leukemia (CML) is a clonal hematologic malignancy characterized by the BCR-ABL protein. BCR-ABL is a constitutively active tyrosine kinase and plays a critical role in the pathogenesis of CML. Imatinib mesylate, a selective tyrosine kinase inhibitor, is effective in CML, but drug resistance and relapse occur. The coiled-coil (CC) domain
Qing Xiao, Miao Gao, Wenli Feng, Mao-Sheng Ji, Kun Tao, Jian-ming Zeng, Liang Zhong, Zhenglan Huang   +7 more
openaire   +3 more sources

Measurement of Free Circulating Bcr-Abl Fusion Protein and Its Phosphorylation in Patients with Chronic Myeloid Leukemia.

Blood, 2005
Abstract Diagnosis and monitoring of therapy in chronic myeloid leukemia (CML) depend on cytogenetic, FISH, and PCR assays for detecting the fusion bcr-abl gene. However, the there is an inherent variability and difficulty in standardizing quantitative PCR-based assays.
Kapil Bhalla, Iman Jilani, Homan Faraji, Oliver G. Ottmann, M. Albitar, Francis J. Giles, Mercedes E. Gorre, Hagop M. Kantarjian, Susan O'Brien, Jorge E. Cortes   +9 more
openaire   +2 more sources

Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference

Leukemia Research, 2005
Nuclear topography, expression of the BCR/ABL fusion gene and its protein level/cellular pattern were studied in CML cell line K562 stimulated to differentiation, apoptosis and influenced by ABL-RNA interference (ABL-RNAi). Phorbol ester-induced maturation of K562 cells was accompanied by repositioning of down-regulated BCR/ABL genes closer to the ...
Jiří Pacherník, Jiří Pacherník, Stanislav Kozubek, Eva Bártová, Andrea Harničarová   +4 more
openaire   +3 more sources

Immunologic Evaluation of Peptides Derived From BCR/ABL-Out-of-Frame Fusion Protein in HLA A2.1 Transgenic Mice

Journal of Immunotherapy, 2012
Philadelphia chromosome-positive chronic myelogenous leukemia and acute lymphocytic leukemia express, besides the main BCR/ABL transcripts, novel BCR/ABL transcripts derived from alternative splicing between BCR exons 1, 13, or 14 with ABL exons 4 and 5. Their translational products present at C-terminus an amino acid portion derived from out-of-frame (
Casnici C, VOLPE, Gisella, Crotta K, Lattuada D, SAGLIO, Giuseppe, Marelli O.   +5 more
openaire   +3 more sources

Flow cytometric bead assay of BCR-ABL fusion proteins in leukemia patients: An Indian experience.

Journal of Clinical Oncology, 2010
6595 Background: The BCR-ABL fusion gene results from the translocation t(9;22). It is the hallmark of chronic myeloid leukemia (CML) and is present in a poor-risk subgroup of precursor B cell acut...
openaire   +2 more sources

HLA class II–restricted antigen presentation of endogenous bcr-abl fusion protein by chronic myelogenous leukemia–derived dendritic cells to CD4+ T lymphocytes

Blood, 2001
Bcr-abl fusion peptide–specific CD4+ T-lymphocyte clones have recently been shown to augment colony formation by chronic myelogenous leukemia (CML) cells in a bcr-abl type-specific and HLA class II–restricted manner without addition of exogenous antigen.
Hisamaru Hirai, Masaki Yasukawa, Kensuke Kojima, Atsuhiko Hasegawa, Takaaki Hato, Tsuyoshi Takahashi, Hideki Ohminami, Shigeru Fujita   +7 more
openaire   +2 more sources

[Preparation and identification of rabbit polyclonal antibody against BCR-ABL b3a2 fusion protein].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2021
Objective To prepare and identify rabbit anti-breakpoint cluster region-Abelson leukemia virus oncogene (BCR-ABL) b3a2 subtype polyclonal antibody. Methods A peptide containing the fusion sequence of the b3a2 subtype BCR-ABL fusion protein was designed and synthesized with the purity higher than 90%. The fusion polypeptide was coupled to Keyhole Limpet
Xiangning, Li, Jiayao, Qu, Jing, Jiang, Li, Wang, Dixian, Luo, Jia, Li, Lili, Duan, Rongzhang, He, Zheng, Hu   +8 more
openaire   +1 more source

A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia

Leukemia Research, 2010
Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL3) would improve the effectiveness ...
Hyun Pyo Kim, Donna E. Hogge, Arthur E. Frankel   +2 more
openaire   +3 more sources