Results 161 to 170 of about 978,977 (295)

Antigenicity analysis of the recombinant fusion proteins NlpI of Mannheimia haemolytica and DsbA of Pasteurella multocida. [PDF]

BMC Vet Res
Xu S, Sun Y, Wei J, Wei Z, Yu J, Jiang M, Zhang H, Sun Z, Wang Z, Wang Z, Wu J, Zhou X.   +11 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Phase-separating fusion proteins drive cancer by upsetting transcription regulation. [PDF]

Genome Biol
Farahi N, Lazar T, Tompa P, Mészáros B, Pancsa R.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Optimized ACE2-Fc fusion proteins with picomolar neutralization activity against highly evolved SARS-CoV-2 variants. [PDF]

Protein Sci
Abancó F, Tarrés-Freixas F, Lepore R, Molina-Molina E, Franco E, Boreika R, Pradenas E, Raïch-Regué D, Erkizia I, Clotet B, Valencia A, Vergara-Alert J, Segalés J, Carrillo J, Izquierdo-Useros N, Blanco J, Trinité B.   +16 more
europepmc   +1 more source

The use of fusion proteins to study HLA-B27-specific allorecognition [PDF]

, 1989
Allen, Arnold, Arnold, Bjorkman, Chen, Clayberger, Clayberger, Dolores J. Schendel, Elisabeth H. Weiss, Gerhild Wildner, Gersten, Gert Riethmüller, Güssow, Hannelore Szöts, Hämmerling, Kourilsky, Lindahl, Lopez de Castro, Maryanski, Nathenson, Neefjes, Ozato, Parham, Sanger, Schendei, Schendel, Schwimmbeck, Seedorf, Stam, Stanley, Szöts, Towbin, Van Pel, Vasilov, Walker, Zinkernagel   +35 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Engineering Fusion Proteins for Nanomedicine-Based Cytokine Therapy. [PDF]

Bioconjug Chem
de Dreu A, de Bruin K, Hokke AM, Schrijver DP, Beelen DNH, Verhalle LM, Clavijo Perez MC, Anbergen T, Versteeg I, Maas R, Zwolsman RC, Grao-Roldán C, Bartelet B, Trines MM, Hoorn D, Ros G, Toner YC, Kluza E, Beldman T, Pérez-Medina C, Netea MG, Merkx M, van der Meel R, Mulder WJM.   +23 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source