Results 11 to 20 of about 979,221 (350)
Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes [PDF]
Communications BiologyViral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The mechanisms by which fusion proteins utilize specific host lipids to drive virus–host membrane fusion remains elusive.
Chetan S. Poojari +2 more
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Comparison of antibody-scTRAIL Fc fusion proteins with varying valency for EGFR and TRAIL receptors [PDF]
Scientific ReportsFusion proteins combining TNF-related apoptosis inducing ligand (TRAIL) and antibody building blocks have emerged as a strategy for the targeted treatment of cancer cells.
Dennis Michler +3 more
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FusionPDB: a knowledgebase of human Fusion Proteins [PDF]
Nucleic Acids Research, 2023 Abstract Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, many fusion proteins are still awaiting being targeted for therapeutics in diverse cellular working mechanisms.
Himansu Kumar +3 more
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Induced degradation of SNAP-fusion proteins [PDF]
RSC Chemical BiologyExtending the applications of the SNAP-tag: VHL- and CRBN-recruiting SNAP-PROTACs provide a ready-to-use targeted protein degradation system for SNAP-fusion proteins.
Savina Abraham Pol +11 more
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RGS1 and CREB5 are direct and common transcriptional targets of ZNF384‐fusion proteins [PDF]
Cancer MedicineBackground ZNF384‐fusion (Z‐fusion) genes were recently identified in B‐cell acute lymphoblastic leukemia (B‐ALL) and are frequent in Japanese adult patients. The frequency is about 20% in those with Philadelphia chromosome‐negative B‐ALL.
Chiharu Yamada +11 more
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Vaccination with Plasmids Encoding the Fusion Proteins D-S1, D-S1N and O-SN from SARS-CoV-2 Induces an Effective Humoral and Cellular Immune Response in Mice [PDF]
VaccinesBackground: Next-generation vaccines against coronavirus disease 2019 (COVID-19) focus on inducing a long-lasting immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its emerging variants.
Noe Juvenal Mendoza-Ramírez +12 more
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Functional Classification of Fusion Proteins in Sarcoma [PDF]
CancersSarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished.
Wachtel, Marco +3 more
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Molecules, 2023 Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research.
Yichao Kong +5 more
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RECOMBINANT HORSERADISH PEROXIDASE FOR ANALYTICAL APPLICATIONS [PDF]
Biotechnologia Acta, 2012 The article deals with prospects of using recombinant horseradish peroxidase in analytical biochemistry and biotechnology. Problems of recombinant horseradish peroxidase cloning in different expression systems, possible approaches to their solution ...
А.M. Egorov +3 more
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Toxins, 2020 The deadly pandemic named COVID-19, caused by a new coronavirus (SARS-CoV-2), emerged in 2019 and is still spreading globally at a dangerous pace. As of today, there are no proven vaccines, therapies, or even strategies to fight off this virus.
Yasser Hassan, Sherry Ogg, Hui Ge
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