Molecular characterization of an MLL1 fusion and its role in chromosomal instability
Molecular Oncology, 2019 Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors?
Sreejit Parameswaran +14 more
doaj +1 more source
The ability to enhance the solubility of its fusion partners is an intrinsic property of maltose-binding protein but their folding is either spontaneous or chaperone-mediated. [PDF]
PLoS ONE, 2012 Escherichia coli maltose binding protein (MBP) is commonly used to promote the solubility of its fusion partners. To investigate the mechanism of solubility enhancement by MBP, we compared the properties of MBP fusion proteins refolded in vitro with ...
Sreejith Raran-Kurussi, David S Waugh
doaj +1 more source
Ca2+-induced fusion of Golgi-derived secretory vesicles isolated from rat liver [PDF]
, 1975 During the transport of plasma proteins from the cytoplasma of hepatocytes to the extracellular fluid srnall vesicles may act as shuttles between the Golgi complex and the plasma membrane.
Ahkong +18 more
core +1 more source
Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants
Frontiers in Molecular Biosciences, 2022 Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione +5 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 1997 Sm15 and Sm13 are recognized by antibodies from mice protectively vaccinated with tegumental membranes, suggesting a potential role in protective immunity.
Frederico GC Abath +4 more
doaj +1 more source
C-terminal eYFP fusion impairs Escherichia coli MinE function [PDF]
Open Biology, 2020 The Escherichia coli Min system plays an important role in the proper placement of the septum ring at mid-cell during cell division. MinE forms a pole-to-pole spatial oscillator with the membrane-bound ATPase MinD, resulting in MinD concentration being ...
Navaneethan Palanisamy +3 more
doaj +1 more source
Membrane fusion of secretory vesicles and liposomes Two different types of fusion [PDF]
, 1981 Secretory vesicles isolated from adrenal medulla were found to fuse in vitro in response to incubation with Ca2+. Intervesicular fusion was detected by electron microscopy and was indicated by the appearance of twinned vesicles in freeze-fractured ...
Akhong +77 more
core +1 more source
Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer [PDF]
, 2016 Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood.
Babu, M. Madan +7 more
core +2 more sources
High-salinity growth conditions promote tat-independent secretion of tat substrates in Bacillus subtilis [PDF]
, 2012 The Gram-positive bacterium Bacillus subtilis contains two Tat translocases, which can facilitate transport of folded proteins across the plasma membrane. Previous research has shown that Tat-dependent protein secretion in B.
Alami +59 more
core +1 more source
Mitochondrial Fusion Proteins and Human Diseases [PDF]
Neurology Research International, 2013 Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important ...
M. Ranieri +7 more
openaire +5 more sources