Results 91 to 100 of about 60,831 (279)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids [PDF]

, 2013
DA - 20130125 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S.
McKain, Nest, Richardson, Anthony J, Wallace, R John   +2 more
core   +2 more sources

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Reassessing taxonomy and virulence in the Fusobacterium nucleatum group—rebuttal of Fusobacterium animalis clades “Fna C1” and “Fna C2,” genome announcement for Fusobacterium watanabei, and description of Fusobacterium paranimalis sp. nov.

mBio
There is a considerable interest in the association between Fusobacterium animalis and colorectal cancer (CRC). Recently, it was suggested that this association is valid only for a distinct clade of F. animalis (Fna C2) and that F.
Audun Sivertsen, Diego Forni, Cristian Molteni, Joanna Bivand, Grete Dimmen, Torbjørn Sæle Bruvold, Manuela Sironi, Øyvind Kommedal   +7 more
doaj   +1 more source

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. [PDF]

, 2020
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of
Gao, Li, Ho, Sunita P, Kamarajan, Pachiyappan, Kang, Misun, Kapila, Yvonne L, Kuraji, Ryutaro, Le, Charles, Martinez, April, Rangé, Hélène, Reza Sailani, M, Ye, Changchang, Zhan, Ling, Zhang, Martin Jinye   +12 more
core  

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance

Cancer Biology & Therapy
Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis.
Chun Ye, Xiao Liu, Zilun Liu, Chuxuan Pan, Xiaowei Zhang, Zhanyi Zhao, Haitao Sun   +6 more
doaj   +1 more source

FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2

Journal of Experimental & Clinical Cancer Research, 2020
Background Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recently.
Pin Guo, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang, Yanan Yu   +10 more
doaj   +1 more source

Genome Sequence of Fusobacterium nucleatum Subspecies Polymorphum — a Genetically Tractable Fusobacterium

PLoS ONE, 2007
Fusobacterium nucleatum is a prominent member of the oral microbiota and is a common cause of human infection. F. nucleatum includes five subspecies: polymorphum, nucleatum, vincentii, fusiforme, and animalis. F. nucleatum subsp. polymorphum ATCC 10953 has been well characterized phenotypically and, in contrast to previously sequenced strains, is ...
Karpathy, Sandor E, Qin, Xiang, Gioia, Jason, Jiang, Huaiyang, Liu, Yamei, Petrosino, Joseph F, Yerrapragada, Shailaja, Fox, George E, Haake, Susan Kinder, Weinstock, George M, Highlander, Sarah K   +10 more
openaire   +5 more sources

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source