Results 71 to 80 of about 60,831 (279)

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

A novel approach to probe host-pathogen interactions of bovine digital dermatitis, a model of a complex polymicrobial infection [PDF]

, 2016
Background: Polymicrobial infections represent a great challenge for the clarification of disease etiology and the development of comprehensive diagnostic or therapeutic tools, particularly for fastidious and difficult-to-cultivate bacteria. Using bovine
Boye, Mette, Jensen, Tim K., Klitgaard, Kirstine, Marcatili, Paolo, Nielsen, Martin W., Nielsen, Morten, Schafer Nielsen, Claus, Sicheritz Ponten, Thomas   +7 more
core   +7 more sources

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Baseline Fusobacterium Abundance Predicts Ustekinumab Response in Crohn's Disease: A Prospective Microbiome Cohort Study

Microbial Biotechnology
The gut microbiota composition in Crohn's disease (CD) patients may influence their response to ustekinumab (UST) therapy. A total of 51 patients with active CD undergoing UST therapy were prospectively enrolled. Clinical activity was evaluated using the
Chengran Wang, Yanping Hao, Yunyun Liu, Le He, Su Xu, Minna Zhang, Xin Wang, Honggang Wang   +7 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Analysis of interspecies adherence of oral bacteria using a membrane binding assay coupled with polymerase chain reaction-denaturing gradient gel electrophoresis profiling. [PDF]

, 2011
Information on co-adherence of different oral bacterial species is important for understanding interspecies interactions within oral microbial community.
He, Xue-song, Hu, Wei, Li, Ji-yao, Lux, Renate, Shi, Wen-yuan, Wang, Ren-ke, Zhou, Xue-dong   +6 more
core  

Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. [PDF]

, 2013
BackgroundEvery genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying sequence and structural analysis we hope
Aravind, L, Axelrod, Herbert L, Bateman, Alex, Chang, Yuanyuan, Coggill, Penelope, Das, Debanu, Eberhardt, Ruth Y, Finn, Robert D, Godzik, Adam, Jaroszewski, Lukasz, Murzin, Alexey G, Xu, Qingping   +11 more
core   +2 more sources

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman   +2 more
wiley   +1 more source

Fusobacterium-associated molecular and immunological alterations in colorectal cancer: Insights from a Norwegian cohort

Frontiers in Immunology
BackgroundThe gut microbiome may significantly influence the development of colorectal cancer (CRC), with Fusobacterium species playing a key role. Recent research has identified Fusobacterium animalis as the predominant Fusobacterium species in CRC ...
Thura Akrem Omran, Jose Luis Subirats Camacho, Jose Luis Subirats Camacho, Thulasika Senthakumaran, Gro Gundersen, Annette Knapskog Alte, Ulla Randen, Ulla Randen, Hege Smith Tunsjø, Per Christian Sæther, Vahid Bemanian   +10 more
doaj   +1 more source

Anaerobic Spondylodiscitis due to Fusobacterium Species: A Case Report Review of the Literature

Case Reports in Infectious Diseases, 2015
Spondylodiscitis caused by Fusobacterium species is rare. Most cases of spontaneous spondylodiscitis are caused by Staphylococcus aureus and most postoperative cases are caused by Staphylococcus aureus or coagulase-negative staphylococci.
Tiffany N. Latta, Aimee L. Mandapat, Joseph P. Myers   +2 more
doaj   +1 more source