Results 41 to 50 of about 5,149 (183)

Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors [PDF]

Synlett, 2023
AbstractGlycans control various biological processes, depending on their structures. Particularly, core fucose, formed by α1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated the development of FUT8 inhibitors with structural elements encompassing both the glycosyl donor (GDP ...
Manabe, Yoshiyuki, Fukase, Koichi, Hizume, Koki, Takakura, Yohei, Takamatsu, Shinji, Miyoshi, Eiji, Kamada, Yoshihiro, Hurtado-Guerrero, Ramón   +7 more
openaire   +2 more sources

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Nature Communications, 2020
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García, Laura Ceballos-Laita, Sonia Serna, Raik Artschwager, Niels C. Reichardt, Francisco Corzana, Ramon Hurtado-Guerrero   +6 more
doaj   +1 more source

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +1 more source

Clinicopathologic significance of FUT8, STX4, and calpain2 expression in ovarian cancer. [PDF]

Am J Transl Res
To investigate the expression of FUT8, STX4, and calpain2 in ovarian tumor tissues and their association with clinicopathological characteristics.This retrospective study analyzed the expression of FUT8, STX4, and calpain2 in ovarian tumor samples from patients treated at Shanghai Pudong New Area People's Hospital between January 1, 2008, and December ...
Yang Y, Wang M, Chen L, Chen X, Wang Y, Ye W.   +5 more
europepmc   +3 more sources

Integrated glycomic analysis of ovarian cancer side population cells [PDF]

, 2016
Additional file 2.
Caiting Yang, Congjian Xu, Haiyan Tai, Hao Wu, Jianxin Gu, Lili Li, Mengyu Zhang, Miaomiao Shao, Peike Peng, Ran Zhao, Ruihuan Qin, Shifang Ren, Wenjun Qin, Xiaoxia Liu, Xiaoxiang Jie, Xingwang Zhang, Yisheng Wang, Yuanyuan Ruan   +17 more
core   +2 more sources

Advances in cancer research on FUT8 molecular mechanisms and clinical applications. [PDF]

Int J Surg
Fucosyltransferase 8 (FUT8) catalyzes core fucosylation, a critical post-translational modification influencing cellular processes. Aberrant core fucosylation is linked to tumor progression, including proliferation, metastasis, and immune evasion. This review integrates the transcriptional and post-transcriptional regulation of FUT8, its interactions ...
Ma Q, Liu Y, Fan Q, Zhu X, Yang D, Zhao Z.   +5 more
europepmc   +3 more sources

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer.

PLoS ONE, 2018
The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers.
Masaru Noda, Hirokazu Okayama, Yasuhide Kofunato, Shun Chida, Katsuharu Saito, Takeshi Tada, Mai Ashizawa, Takahiro Nakajima, Keita Aoto, Tomohiro Kikuchi, Wataru Sakamoto, Hisahito Endo, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono   +16 more
doaj   +1 more source

N6‐methyladenosine‐modified circFUT8 competitively interacts with YTHDF2 and miR‐186‐5p to stabilize FUT8 mRNA to promote malignant progression in lung adenocarcinoma

Thoracic Cancer, 2023
Background Lung cancer is the leading cause of cancer related to mortality worldwide, and the main pathological type is lung adenocarcinoma (LUAD). Circular RNAs (circRNAs) have been reported to be modified by N6‐methyladenosine (m6A), which is involved ...
Gaochao Dong, Yingkuan Liang, Bing Chen, Te Zhang, Hui Wang, Yuzhong Chen, Yijian Zhang, Feng Jiang, Yaping Wang   +8 more
doaj   +1 more source

α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Cells, 2022
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans.
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa   +7 more
doaj   +1 more source

Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota

Frontiers in Microbiology, 2020
The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li   +8 more
doaj   +1 more source