Results 21 to 30 of about 3,592,863 (264)
Scientific Reports, 2018 CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.
Gundeep Kaur +5 more
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Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus
Pathogens, 2020 The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various
Hee-Soo Park +3 more
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The Disruption of a Gα Subunit Sheds New Light on the Pathogenicity of Stagonospora nodorum on Wheat
Molecular Plant-Microbe Interactions, 2004 Gna1, a gene encoding a Gα subunit, a key component of signal transduction pathways, has been cloned and characterized in the wheat pathogen Stagonospora nodorum.
Peter S. Solomon +4 more
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DEER Analysis of GPCR Conformational Heterogeneity
Biomolecules, 2021 G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Role of TAS2R38 polymorphism in respiratory diseases pathogenesis
Медицинская иммунологияMore and more new data, concerning extraoral bitter taste receptors (TAS2R), appear now. Current data on polymorphisms, expression patterns and form of TAS2R subtype 38 (TAS2R38), its molecular variants that differ in the degrees of sensitivity to ...
M. A. Nyoma, R. G. Murkina, V. N. Mineev
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
wiley +1 more source
Diabetıc Cardiomyopathy And G Protein
Van Tıp Dergisi, 2019 Diabetes mellitus (DM) is one of the most important disease in the modern society and represents not only a medical but also social problem. Cardiovascular disease is the primary cause of death in people with either type 1 or type 2 diabetes.
Yasemin Behram Kandemir +3 more
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Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, 2020 Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang +7 more
doaj +1 more source
Interaction of class A G protein-coupled receptors with G proteins.
Acta Biochimica Polonica, 2004 A model for interaction of class A G protein-coupled receptor with the G protein G(alpha) subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gt(alpha) C-terminal peptide bound to RD* while stabilizing it.
Rafał, Slusarz, Jerzy, Ciarkowski
openaire +3 more sources