Results 41 to 50 of about 18,235,278 (306)
On the hierarchical classification of G Protein-Coupled Receptors [PDF]
, 2007 Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies +11 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source
Diabetıc Cardiomyopathy And G Protein
Van Tıp Dergisi, 2019 Diabetes mellitus (DM) is one of the most important disease in the modern society and represents not only a medical but also social problem. Cardiovascular disease is the primary cause of death in people with either type 1 or type 2 diabetes.
Yasemin Behram Kandemir +3 more
doaj +1 more source
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, 2020 Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang +7 more
doaj +1 more source
Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]
, 2009 Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core
Salting the charged surface: pH and salt dependence of protein G B1 stability. [PDF]
, 2006 This study shows significant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt ...
Xue, Wei-Feng +19 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
, 2012 The classical view of heterotrimeric G protein signaling places G -proteins at the cytoplasmic surface of the cell's plasma membrane where they are activated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C ...
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
G Protein-Linked Signaling Pathways in Bipolar and Major Depressive Disorders
Frontiers in Genetics, 2013 The G-protein linked signaling system (GPLS) comprises a large number of G-proteins, G protein-coupled receptors (GPCRs), GPCR ligands, and downstream effector molecules.
Hiroaki eTomita +18 more
doaj +1 more source