Results 1 to 10 of about 647,242 (293)

Peptide ligand recognition by G protein-coupled receptors [PDF]

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +6 more sources

Acidic Tumor Microenvironment and pH-Sensing G protein-Coupled Receptors [PDF]

Frontiers in Physiology, 2013
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic ...
Calvin R. Justus, Lixue eDong, Li V. Yang   +2 more
doaj   +4 more sources

Role of G protein coupled receptors in acute kidney injury [PDF]

Cell Communication and Signaling
Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney.
Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao   +7 more
doaj   +2 more sources

G protein-coupled receptors and obesity

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
doaj   +1 more source

G Protein-Coupled Receptors in Osteoarthritis

Frontiers in Endocrinology, 2022
Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there are no available therapies being able to modify the progression of OA and prevent long-term disability. Critical roles of G-protein coupled receptors (GPCRs) have
Fanhua Wang, Mingyao Liu, Ning Wang, Jian Luo, Jian Luo   +4 more
doaj   +1 more source

Hemorphins Targeting G Protein-Coupled Receptors

Pharmaceuticals, 2021
Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
doaj   +1 more source

Advances on Mrgprs itch receptors and their ligands

Pifu-xingbing zhenliaoxue zazhi, 2023
Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
doaj   +1 more source

Functional optimization of light-activatable Opto-GPCRs: Illuminating the importance of the proximal C-terminus in G-protein specificity

Frontiers in Cell and Developmental Biology, 2023
Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process.
Siri Leemann, Sonja Kleinlogel
doaj   +1 more source

Designer lipid-like peptides [PDF]

, 2011
A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Baaske, Philipp, Braun, Dieter, Brown, Emily, Corin, Karolina, Duhr, Stefan, Jerabek-Willemsen, Moran, Luo, Yuan, Ravel, Deepali B., Song, Junyao, Wang, Xiaoqiang, Wienken, Christoph J., Zhang, Shuguang   +11 more
core   +7 more sources

Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium

Royal Society Open Science, 2022
Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation.
Rebecca Claßen, Ervice Pouokam, Matthias Wickleder, Martin Diener, Annabelle Mattern   +4 more
doaj   +1 more source