Results 201 to 210 of about 774,543 (406)

Primary Alcohols Modulate the Activation of the G Protein-coupled Receptor Rhodopsin by a Lipid-mediated Mechanism [PDF]

, 1996
Drake C. Mitchell, J. Todd R. Lawrence, Burton J. Litman   +2 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

A Role for Receptor Kinases in the Regulation of Class II G Protein-coupled Receptors [PDF]

, 1998
Michael A. Shetzline, Richard T. Premont, Julia K. L. Walker, Steven R. Vigna, Marc G. Caron   +4 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

G Protein–Coupled Receptor Kinases: Crucial Regulators of Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Jian Yang, Van Anthony M. Villar, Ines Armando, Pedro A. Jose, Chunyu Zeng   +4 more
doaj   +1 more source

Molecular tinkering of G protein‐coupled receptors: an evolutionary success

EMBO Journal, 1999
J. Bockaert, Jean Philippe Pin
semanticscholar   +1 more source

Use of a Sandwich Enzyme-linked Immunosorbent Assay Strategy to Study Mechanisms of G Protein-coupled Receptor Assembly [PDF]

, 1999
Ján Jakubík, Jürgen Wess
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Trace amines: Identification of a family of mammalian G protein-coupled receptors

Proceedings of the National Academy of Sciences of the United States of America, 2001
B. Borowsky, N. Adham, K. A. Jones, R. Raddatz, R. Artymyshyn, K. Ogozalek, M. Durkin, P. Lakhlani, J. A. Bonini, S. Pathirana, N. Boyle, Xiaosui Pu, E. Kouranova, H. Lichtblau, F. Y. Ochoa, T. Branchek, C. Gerald   +16 more
semanticscholar   +1 more source

Molecular Cloning and Characterization of a Novel Retinoic Acid-inducible Gene That Encodes a Putative G Protein-coupled Receptor [PDF]

, 1998
Yijun Cheng, Reuben Lotan
openalex   +1 more source