The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors*
Journal of Biological Chemistry, 2016 The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion,
Jeffrey S. Smith, S. Rajagopal
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G Protein–Coupled Receptor Rhodopsin [PDF]
Annual Review of Biochemistry, 2006 The rhodopsin crystal structure provides a structural basis for understanding the function of this and other G protein–coupled receptors (GPCRs). The major structural motifs observed for rhodopsin are expected to carry over to other GPCRs, and the mechanism of transformation of the receptor from inactive to active forms is thus likely conserved ...
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Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
eLife, 2018 The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule ...
Javier García-Nafría +4 more
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Neomycin induces high‐affinity agonist binding of G‐protein‐coupled receptors [PDF]
, 1989 Eva Herrmann +2 more
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The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors
British Journal of Pharmacology, 2013 The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Stephen P. H. Alexander +7 more
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GPCRDB: an information system for G protein-coupled receptors
Nucleic Acids Res., 2013 For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a ‘one-stop shop’ for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants,
Vignir Ísberg +5 more
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Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?
Frontiers in Oncology, 2018 In mammals, numerous organ systems are equipped with adhesion G protein-coupled receptors (aGPCRs) to shape cellular processes including migration, adhesion, polarity and guidance.
Nicole Scholz
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Adhesion G Protein-Coupled Receptors as Drug Targets.
Annual Review of Pharmacology and Toxicology, 2018 The adhesion G protein-coupled receptors (aGPCRs) are an evolutionarily ancient family of receptors that play key roles in many different physiological processes.
Ryan H Purcell, Randy A. Hall
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GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. [PDF]
, 1993 Stephen M. Strittmatter +4 more
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Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor. [PDF]
, 1993 Z Wang, H Wang, Mario Ascoli
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