Results 1 to 10 of about 14,208,503 (293)
Molecules, 2019 G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or ...
Zhi-Yin Sun +4 more
doaj +2 more sources
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
Molecules, 2019 The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional
Martin Bartas +9 more
doaj +2 more sources
iScience, 2021 Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu +2 more
doaj +1 more source
iScience, 2022 Summary: DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform the algorithm profiling and genome-wide ...
Xiaolin Wang +10 more
doaj +1 more source
G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
Molecules, 2023 G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions ...
Yan Xu, Makoto Komiyama
doaj +1 more source
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023 Determination of G-quadruplex formation in DNA is required for the design of small molecules (drugs) targeting G-quadruplex. In previous studies, we used the fluorescent protein RHAU53-CFP capable of recognizing parallel G-quadruplex structures through a
Trương Thị Tinh Tươm +3 more
doaj +1 more source
DNA G-quadruplex structures: more than simple roadblocks to transcription?
Nucleic Acids Research, 2021 It has been >20 years since the formation of G-quadruplex (G4) secondary structures in gene promoters was first linked to the regulation of gene expression.
Jenna Robinson +4 more
semanticscholar +1 more source
PLoS ONE, 2022 GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem +2 more
doaj +3 more sources
Accounts of Chemical Research, 2022 ConspectusDNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets.
Luying Chen +3 more
semanticscholar +1 more source
Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Pharmaceuticals, 2021 The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
doaj +1 more source