Results 261 to 270 of about 12,561,590 (387)

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

Nature, 2018
Michael C. Chen, Ramreddy Tippana, N. Demeshkina, Pierre Murat, S. Balasubramanian, Sua Myong, A. Ferré-D’Amaré   +6 more
semanticscholar   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Computational Analysis Uncovering Contrasts in G-Quadruplex Propensity and Aptamer Enrichment in SELEX-Derived Libraries. [PDF]

Chembiochem
Liu G, Wu TY, Kwok CK, Liu J.
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Probing Residual Water in G-Quadruplex Structures through Molecular Vibrations. [PDF]

J Phys Chem B
Libera V, Catalini S, Ripanti F, Bertini L, Alunni Cardinali M, D'Amico F, Orecchini A, Petrillo C, Paolantoni M, Paciaroni A, Comez L.   +10 more
europepmc   +1 more source

Retraction notice to “Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy” [European Journal of Pharmaceutical Sciences 125 (2018) Pages 39-53]

Rudradip Pattanayak, Atish Barua, Amlan Das, Tanima Chatterjee, Adrija Pathak, Pritha Choudhury, Srikanta Sen, Prosenjit Saha, Maitree Bhattacharyya   +8 more
openalex   +1 more source

Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay

, 2019
Ján Jamroškovič, Ikenna Obi, Anahita Movahedi, Karam Chand, Erik Chorell, Nasim Sabouri   +5 more
openalex   +1 more source

Folding pathways of human telomeric hybrid G-quadruplex structure [PDF]

, 2007
Tomoji Mashimo, Hiroshi Sugiyama
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Molecular Tools for Precision Targeting and Detection of G-Quadruplex Structures. [PDF]

Molecules
Esposito D, Locatelli A, Morigi R.
europepmc   +1 more source