Results 271 to 280 of about 12,561,590 (387)

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

RNA G-Quadruplex RIBOTAC-Mediated Targeted Degradation of lncRNA TERRA. [PDF]

Adv Sci (Weinh)
Khaskia E, Dahatonde D, Benhamou RI.
europepmc   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Helical aromatic oligoamide foldamers as selective G-quadruplex ligands. [PDF]

Nucleic Acids Res
König A, Laffilé V, Thore S, Mackereth CD, Yatsunyk LA, Ferrand Y, Largy E, Gabelica V.   +7 more
europepmc   +1 more source

G-Quadruplex Guanosine Gels and Single Walled Carbon Nanotubes [PDF]

, 2013
Yuehua Yu, V. Pushparaj, Omkaram Nalamasu, Linda B. McGown   +3 more
openalex   +1 more source

Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches

Advanced Science, EarlyView.
The fundamental principles linking nanoparticle (NP) physicochemical properties to their interactions with sonomechanical forces are not well‐defined. This work systematically investigates the size‐dependent ultrasound activation of thrombin using different‐sized mechano‐nanoswitches, which provides critical insights into the role of NP size in nano ...
Menghan Xiao, Zhihuan Liao, Junliang Chen, Xiong Zuo, Jiangting Zeng, Xiangfu Du, Zihao Teng, Johannes Hahmann, Andreas Herrmann, Shuaidong Huo   +9 more
wiley   +1 more source

Kinetic analysis of catalytic activity of G-quadruplex/hemin DNAzyme with flanking adenine nucleotides. [PDF]

Sci Rep
Udomprasert A, Chimasungkanun S, Kangsamaksin T.   +2 more
europepmc   +1 more source

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

, 2020
Michael O’Hagan, Javier Ramos‐Soriano, Susanta Haldar, Sadiyah Sheikh, Juan Carlos Morales, Adrian J. Mulholland, M. Carmen Galán   +6 more
openalex   +2 more sources

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress. [PDF]

Commun Biol
Bonanni L, Muoio D, Fouquerel E, Perelli A, Salvati E, Berardinelli F, Antoccia A.   +6 more
europepmc   +1 more source