Results 21 to 30 of about 12,561,590 (387)
Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space
Pharmaceuticals, 2022 The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak +3 more
doaj +1 more source
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Nature Communications, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules,
Geng Liu +11 more
semanticscholar +1 more source
Heliyon, 2023 G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag +2 more
doaj +1 more source
RNA G-quadruplex structure contributes to cold adaptation in plants
bioRxiv, 2022 Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown ...
Xiaofei Yang +9 more
semanticscholar +1 more source
Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]
, 2020 BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S +9 more
core +2 more sources
G-quadruplex organic frameworks [PDF]
Nature Chemistry, 2016 Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu +11 more
openaire +3 more sources
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
openaire +3 more sources
Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. [PDF]
PLoS ONE, 2013 With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation.
Li-Ping Bai +5 more
doaj +1 more source
Computational studies of the interactions between quinazolone derivatives and G-quadruplex DNA as an anticancer strategy [PDF]
شیمی کاربردی روز, 2015 In recent years, stabilization of G-quadruplex structures with small molecules has attracted considerable attentions as a promising target for cancer therapy.
Kiana Gholamjani Moghaddam +1 more
doaj +1 more source
On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents
International Journal of Molecular Sciences, 2021 Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell ...
Irene Alessandrini +3 more
semanticscholar +1 more source