Results 21 to 30 of about 14,208,503 (293)
G-quadruplex organic frameworks [PDF]
Nature Chemistry, 2016 Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and ...
Yi-Lin Wu +11 more
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On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents
International Journal of Molecular Sciences, 2021 Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell ...
Irene Alessandrini +3 more
semanticscholar +1 more source
G-quadruplexes and helicases [PDF]
Nucleic Acids Research, 2016 Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures.
Mendoza, Oscar +4 more
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Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. [PDF]
PLoS ONE, 2013 With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation.
Li-Ping Bai +5 more
doaj +1 more source
Computational studies of the interactions between quinazolone derivatives and G-quadruplex DNA as an anticancer strategy [PDF]
شیمی کاربردی روز, 2015 In recent years, stabilization of G-quadruplex structures with small molecules has attracted considerable attentions as a promising target for cancer therapy.
Kiana Gholamjani Moghaddam +1 more
doaj +1 more source
Multistep mechanism of G-quadruplex resolution during DNA replication
Science Advances, 2021 DNA helicases DHX36 and FANCJ constitute a previously unknown pathway that resolves G-quadruplex structures during DNA replication.
Koichi Sato +4 more
semanticscholar +1 more source
G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
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Simultaneous G‐Quadruplex DNA Logic [PDF]
Chemistry – A European Journal, 2018 AbstractA fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base‐pairing.
Antoine Bader, Scott L. Cockroft
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npj Biofilms and Microbiomes, 2021 Extracellular DNA, or eDNA, is recognised as a critical biofilm component; however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids to preserve ...
T. Seviour +14 more
semanticscholar +1 more source
Polyelectrolyte effects in G-quadruplexes [PDF]
Biophysical Chemistry, 2013 The role of counterion condensation as a dominant force governing the stability of DNA duplexes and triplexes is well established. In contrast, the effect of counterion condensation on the stability of G-quadrupex conformations is poorly understood. Unlike other ordered nucleic acid structures, G-quadruplexes exhibit a specific binding of counterions ...
Kim, Byul +2 more
openaire +2 more sources