Results 31 to 40 of about 14,208,503 (293)
G-quadruplexes rescuing protein folding
Proceedings of the National Academy of Sciences, 2023 Maintaining the health of the proteome is a critical cellular task. Recently, we found G-quadruplex (G4) nucleic acids are especially potent at preventing protein aggregation in vitro and could at least indirectly improve the protein folding environment of Escherichia coli .
Ahyun Son +4 more
openaire +2 more sources
Molecules, 2013 Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. A derivative having a 2-(dimethylamino)ethyl chain attached to the 5-position of the phenyl ring was recently identified as a selective G ...
Joseph E. Rice +7 more
doaj +1 more source
Re-evaluation of G-quadruplex propensity with G4Hunter
Nucleic Acids Research, 2016 Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms.
A. Bedrat, L. Lacroix, J. Mergny
semanticscholar +1 more source
GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner. [PDF]
PLoS ONE, 2016 G-quadruplexes are one of the most commonly studied non-B DNA structures. Generally, these structures are formed using a minimum of 4, three guanine tracts, with connecting loops ranging from one to seven. Recent studies have reported deviation from this
Kohal Das +2 more
doaj +1 more source
Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability
Microorganisms, 2020 G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh +5 more
doaj +1 more source
Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications
Journal of Nucleic Acids, 2018 Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology.
Ana-Maria Chiorcea-Paquim +2 more
doaj +1 more source
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Nature Communications, 2017 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect.
Hong Xu +38 more
semanticscholar +1 more source
G-quadruplexes in helminth parasites
Nucleic Acids Research, 2022 Abstract Parasitic helminths infecting humans are highly prevalent infecting ∼2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morbidity. In addition, helminth infections of cattle have a significant economic impact on livestock production, milk yield and fertility.
Cantara, Alessio +13 more
openaire +4 more sources
Synthesis of copper (II) porphyrin complexes and their interaction with c-myc G-quadruplex DNA
Journal of Holistic Integrative Pharmacy, 2021 Objective: To synthesize copper (II) porphyrin complexes and study their interactions with c-myc G-quadruplex DNA. Methods: The 5-p-hydroxyphenyl-10, 15, 20-tris (p-methoxyphenyl) copper (II) porphyrin complex [p-HTMOPPCu (II)] was synthesized by the ...
Kunxian YANG +7 more
doaj +1 more source
Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2017 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs.
Clement, Lin, Danzhou, Yang
openaire +2 more sources